Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters: A twin study

Research output: Contribution to journalArticle

Adam D. Tarnoki, David L. Tarnoki, Pal Bata, Levente Littvay, Janos Osztovits, Gyorgy Jermendy, Kinga Karlinger, Agnes Lannert, Istvan Preda, Robert G. Kiss, Andrea A. Molnar, Zsolt Garami, Gyorgy Baffy, Viktor Berczi

Background: Non-alcoholic fatty liver disease (NAFLD) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims: To analyse heritability of NAFLD and its association with abnormal vascular parameters in a large twin cohort. Methods: Anthropometric and lipid metabolic parameters were obtained from 208 adult Hungarian twins (63 monozygotic and 41 dizygotic pairs; 58 men and 150 women; age 43.7 ± 16.7 years). B-mode ultrasonography was performed to detect steatosis and categorize severity. Brachial and aortic augmentation indices and aortic pulse wave velocity were assessed using oscillometry (TensioMed Arteriograph). Carotid intima media thickness (IMT) was measured using ultrasonography on the proximal common, distal common and internal carotid arteries. Results: NAFLD was identified in 47 subjects (22.6%), of which 44 (93.6%) had mild and 3 (6.4%) had moderate steatosis. These subjects were older (age: 50.9 ± 14.3 vs. 41.5 ± 16.7 years, P < 0.001) and had a higher body mass index (BMI; 30.1 ± 5.2 vs. 24.6 ± 4.1 km/m2, P < 0.001) than non-NAFLD twins. Based on 91 same-sex twin pairs, heritability analysis indicated no discernible role for genetic components in the presence of NAFLD (95% confidence interval, 0.0-36.0%), while shared and unshared environmental effects accounted for 74.2% and 25.8% of variations adjusted for age and BMI. Augmentation indices and carotid IMT in twins with NAFLD were increased at most examined locations (P < 0.05-P < 0.001). Conclusion: These findings do not support heritability of NAFLD, although it coexists with vascular parameters linked to increased cardiovascular risk, underscoring the importance and value of prevention in this very common disorder.

Original languageEnglish
Pages (from-to)1287-1293
Number of pages7
JournalLiver International
Volume32
Issue number8
DOIs
StatePublished - Sep 1 2012

PMID: 22651705

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Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters : A twin study. / Tarnoki, Adam D.; Tarnoki, David L.; Bata, Pal; Littvay, Levente; Osztovits, Janos; Jermendy, Gyorgy; Karlinger, Kinga; Lannert, Agnes; Preda, Istvan; Kiss, Robert G.; Molnar, Andrea A.; Garami, Zsolt; Baffy, Gyorgy; Berczi, Viktor.

In: Liver International, Vol. 32, No. 8, 01.09.2012, p. 1287-1293.

Research output: Contribution to journalArticle

Harvard

Tarnoki, AD, Tarnoki, DL, Bata, P, Littvay, L, Osztovits, J, Jermendy, G, Karlinger, K, Lannert, A, Preda, I, Kiss, RG, Molnar, AA, Garami, Z, Baffy, G & Berczi, V 2012, 'Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters: A twin study' Liver International, vol. 32, no. 8, pp. 1287-1293. https://doi.org/10.1111/j.1478-3231.2012.02823.x

APA

Tarnoki, A. D., Tarnoki, D. L., Bata, P., Littvay, L., Osztovits, J., Jermendy, G., ... Berczi, V. (2012). Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters: A twin study. Liver International, 32(8), 1287-1293. https://doi.org/10.1111/j.1478-3231.2012.02823.x

Vancouver

Tarnoki AD, Tarnoki DL, Bata P, Littvay L, Osztovits J, Jermendy G et al. Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters: A twin study. Liver International. 2012 Sep 1;32(8):1287-1293. https://doi.org/10.1111/j.1478-3231.2012.02823.x

Author

Tarnoki, Adam D. ; Tarnoki, David L. ; Bata, Pal ; Littvay, Levente ; Osztovits, Janos ; Jermendy, Gyorgy ; Karlinger, Kinga ; Lannert, Agnes ; Preda, Istvan ; Kiss, Robert G. ; Molnar, Andrea A. ; Garami, Zsolt ; Baffy, Gyorgy ; Berczi, Viktor. / Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters : A twin study. In: Liver International. 2012 ; Vol. 32, No. 8. pp. 1287-1293.

BibTeX

@article{501f573f383d430c852cc8de1097af0a,
title = "Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters: A twin study",
abstract = "Background: Non-alcoholic fatty liver disease (NAFLD) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims: To analyse heritability of NAFLD and its association with abnormal vascular parameters in a large twin cohort. Methods: Anthropometric and lipid metabolic parameters were obtained from 208 adult Hungarian twins (63 monozygotic and 41 dizygotic pairs; 58 men and 150 women; age 43.7 ± 16.7 years). B-mode ultrasonography was performed to detect steatosis and categorize severity. Brachial and aortic augmentation indices and aortic pulse wave velocity were assessed using oscillometry (TensioMed Arteriograph). Carotid intima media thickness (IMT) was measured using ultrasonography on the proximal common, distal common and internal carotid arteries. Results: NAFLD was identified in 47 subjects (22.6{\%}), of which 44 (93.6{\%}) had mild and 3 (6.4{\%}) had moderate steatosis. These subjects were older (age: 50.9 ± 14.3 vs. 41.5 ± 16.7 years, P < 0.001) and had a higher body mass index (BMI; 30.1 ± 5.2 vs. 24.6 ± 4.1 km/m2, P < 0.001) than non-NAFLD twins. Based on 91 same-sex twin pairs, heritability analysis indicated no discernible role for genetic components in the presence of NAFLD (95{\%} confidence interval, 0.0-36.0{\%}), while shared and unshared environmental effects accounted for 74.2{\%} and 25.8{\%} of variations adjusted for age and BMI. Augmentation indices and carotid IMT in twins with NAFLD were increased at most examined locations (P < 0.05-P < 0.001). Conclusion: These findings do not support heritability of NAFLD, although it coexists with vascular parameters linked to increased cardiovascular risk, underscoring the importance and value of prevention in this very common disorder.",
keywords = "Arterial stiffness, Genetics, Heritability, Intima media thickness, Steatosis",
author = "Tarnoki, {Adam D.} and Tarnoki, {David L.} and Pal Bata and Levente Littvay and Janos Osztovits and Gyorgy Jermendy and Kinga Karlinger and Agnes Lannert and Istvan Preda and Kiss, {Robert G.} and Molnar, {Andrea A.} and Zsolt Garami and Gyorgy Baffy and Viktor Berczi",
year = "2012",
month = "9",
day = "1",
doi = "10.1111/j.1478-3231.2012.02823.x",
language = "English",
volume = "32",
pages = "1287--1293",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley",
number = "8",

}

RIS

TY - JOUR

T1 - Heritability of non-alcoholic fatty liver disease and association with abnormal vascular parameters

T2 - Liver International

AU - Tarnoki, Adam D.

AU - Tarnoki, David L.

AU - Bata, Pal

AU - Littvay, Levente

AU - Osztovits, Janos

AU - Jermendy, Gyorgy

AU - Karlinger, Kinga

AU - Lannert, Agnes

AU - Preda, Istvan

AU - Kiss, Robert G.

AU - Molnar, Andrea A.

AU - Garami, Zsolt

AU - Baffy, Gyorgy

AU - Berczi, Viktor

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Background: Non-alcoholic fatty liver disease (NAFLD) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims: To analyse heritability of NAFLD and its association with abnormal vascular parameters in a large twin cohort. Methods: Anthropometric and lipid metabolic parameters were obtained from 208 adult Hungarian twins (63 monozygotic and 41 dizygotic pairs; 58 men and 150 women; age 43.7 ± 16.7 years). B-mode ultrasonography was performed to detect steatosis and categorize severity. Brachial and aortic augmentation indices and aortic pulse wave velocity were assessed using oscillometry (TensioMed Arteriograph). Carotid intima media thickness (IMT) was measured using ultrasonography on the proximal common, distal common and internal carotid arteries. Results: NAFLD was identified in 47 subjects (22.6%), of which 44 (93.6%) had mild and 3 (6.4%) had moderate steatosis. These subjects were older (age: 50.9 ± 14.3 vs. 41.5 ± 16.7 years, P < 0.001) and had a higher body mass index (BMI; 30.1 ± 5.2 vs. 24.6 ± 4.1 km/m2, P < 0.001) than non-NAFLD twins. Based on 91 same-sex twin pairs, heritability analysis indicated no discernible role for genetic components in the presence of NAFLD (95% confidence interval, 0.0-36.0%), while shared and unshared environmental effects accounted for 74.2% and 25.8% of variations adjusted for age and BMI. Augmentation indices and carotid IMT in twins with NAFLD were increased at most examined locations (P < 0.05-P < 0.001). Conclusion: These findings do not support heritability of NAFLD, although it coexists with vascular parameters linked to increased cardiovascular risk, underscoring the importance and value of prevention in this very common disorder.

AB - Background: Non-alcoholic fatty liver disease (NAFLD) has been linked to increased cardiovascular morbidity. However, genetic factors have an unclear role in this condition. Aims: To analyse heritability of NAFLD and its association with abnormal vascular parameters in a large twin cohort. Methods: Anthropometric and lipid metabolic parameters were obtained from 208 adult Hungarian twins (63 monozygotic and 41 dizygotic pairs; 58 men and 150 women; age 43.7 ± 16.7 years). B-mode ultrasonography was performed to detect steatosis and categorize severity. Brachial and aortic augmentation indices and aortic pulse wave velocity were assessed using oscillometry (TensioMed Arteriograph). Carotid intima media thickness (IMT) was measured using ultrasonography on the proximal common, distal common and internal carotid arteries. Results: NAFLD was identified in 47 subjects (22.6%), of which 44 (93.6%) had mild and 3 (6.4%) had moderate steatosis. These subjects were older (age: 50.9 ± 14.3 vs. 41.5 ± 16.7 years, P < 0.001) and had a higher body mass index (BMI; 30.1 ± 5.2 vs. 24.6 ± 4.1 km/m2, P < 0.001) than non-NAFLD twins. Based on 91 same-sex twin pairs, heritability analysis indicated no discernible role for genetic components in the presence of NAFLD (95% confidence interval, 0.0-36.0%), while shared and unshared environmental effects accounted for 74.2% and 25.8% of variations adjusted for age and BMI. Augmentation indices and carotid IMT in twins with NAFLD were increased at most examined locations (P < 0.05-P < 0.001). Conclusion: These findings do not support heritability of NAFLD, although it coexists with vascular parameters linked to increased cardiovascular risk, underscoring the importance and value of prevention in this very common disorder.

KW - Arterial stiffness

KW - Genetics

KW - Heritability

KW - Intima media thickness

KW - Steatosis

UR - http://www.scopus.com/inward/record.url?scp=84865173047&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865173047&partnerID=8YFLogxK

U2 - 10.1111/j.1478-3231.2012.02823.x

DO - 10.1111/j.1478-3231.2012.02823.x

M3 - Article

VL - 32

SP - 1287

EP - 1293

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 8

ER -

ID: 3270138