Heritability of central blood pressure and arterial stiffness: A twin study

Research output: Contribution to journalArticle

Adam Domonkos Tarnoki, David Laszlo Tarnoki, Maria Antonietta Stazi, Emanuela Medda, Rodolfo Cotichini, Lorenza Nisticò, Corrado Fagnani, Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Fabrizio Fanelli, Claudio Baracchini, Giorgio Meneghetti, Janos Osztovits, Gyorgy Jermendy, István Préda, Róbert Gábor Kiss, Julia Metneki, Tamas Horvath, Kinga Karlinger & 7 others Adel Racz, Agnes Lannert, Andrea Agnes Molnar, Levente Littvay, Zsolt Garami, Viktor Berczi, Giuseppe Schillaci

Objective: Central blood pressure and aortic stiffness have been consistently reported as strong cardiovascular risk factors. Twin studies by comparing identical with nonidentical twins produce information on the relative contribution of genes and environment. Methods: One hundred and fifty-four monozygotic (MZ) and 42 dizygotic (DZ) twin pairs (age 43±17 years) from Hungary and the United States underwent brachial and central augmentation index (AIx), brachial and central pressure, and aortic pulse wave velocity (PWV) measurements with the invasively validated Arteriograph device. Bivariate Cholesky decomposition models were applied. Results: Age-adjusted, sex-adjusted and country-adjusted heritability was 60.0% for central SBP [95% confidence interval (CI), 44.8-69.6%], 50.1% for aortic PWV (95%CI, 26.0-66.8%), 48.7% for aortic AIx (95%CI, 1.7-74.0%), 46.8% for brachial AIx (95%CI, 1.1-73.8%), 46.7% for central pulse pressure (PP) (95%CI, 12.4-61.4%), and 30.0% for brachial PP (95%CI, 0.0-53.4%). Central SBP and PP had strong bivariate correlations with brachial (r=0.461 and 0.425) and central AIx (r=0.457 and 0.419), as well as with aortic PWV (r=0.341 and 0.292, all P<0.001). Brachial PP had a weak correlation with brachial AIx (r=-0.118, P<0.05), central AIx (r=-0.122, P<0.05), and none with aortic PWV (r=0.08, P=n.s.). Genetic factors explained a moderate phenotypic correlation between central PP, SBP, brachial SBP and aortic PWV. Conclusions: Central systolic and PPs, brachial PP, AIx, aortic PWV are moderately heritable. A moderate genetic covariance among aortic PWV and central PP, central SBP and brachial SBP was found.

Original languageEnglish
Pages (from-to)1564-1571
Number of pages8
JournalJournal of Hypertension
Issue number8
StatePublished - Aug 1 2012

PMID: 22688268


Cite this


Heritability of central blood pressure and arterial stiffness : A twin study. / Tarnoki, Adam Domonkos; Tarnoki, David Laszlo; Stazi, Maria Antonietta; Medda, Emanuela; Cotichini, Rodolfo; Nisticò, Lorenza; Fagnani, Corrado; Lucatelli, Pierleone; Boatta, Emanuele; Zini, Chiara; Fanelli, Fabrizio; Baracchini, Claudio; Meneghetti, Giorgio; Osztovits, Janos; Jermendy, Gyorgy; Préda, István; Kiss, Róbert Gábor; Metneki, Julia; Horvath, Tamas; Karlinger, Kinga; Racz, Adel; Lannert, Agnes; Molnar, Andrea Agnes; Littvay, Levente; Garami, Zsolt; Berczi, Viktor; Schillaci, Giuseppe.

In: Journal of Hypertension, Vol. 30, No. 8, 01.08.2012, p. 1564-1571.

Research output: Contribution to journalArticle


Tarnoki, AD, Tarnoki, DL, Stazi, MA, Medda, E, Cotichini, R, Nisticò, L, Fagnani, C, Lucatelli, P, Boatta, E, Zini, C, Fanelli, F, Baracchini, C, Meneghetti, G, Osztovits, J, Jermendy, G, Préda, I, Kiss, RG, Metneki, J, Horvath, T, Karlinger, K, Racz, A, Lannert, A, Molnar, AA, Littvay, L, Garami, Z, Berczi, V & Schillaci, G 2012, 'Heritability of central blood pressure and arterial stiffness: A twin study' Journal of Hypertension, vol. 30, no. 8, pp. 1564-1571. https://doi.org/10.1097/HJH.0b013e32835527ae


Tarnoki, A. D., Tarnoki, D. L., Stazi, M. A., Medda, E., Cotichini, R., Nisticò, L., ... Schillaci, G. (2012). Heritability of central blood pressure and arterial stiffness: A twin study. Journal of Hypertension, 30(8), 1564-1571. https://doi.org/10.1097/HJH.0b013e32835527ae


Tarnoki AD, Tarnoki DL, Stazi MA, Medda E, Cotichini R, Nisticò L et al. Heritability of central blood pressure and arterial stiffness: A twin study. Journal of Hypertension. 2012 Aug 1;30(8):1564-1571. https://doi.org/10.1097/HJH.0b013e32835527ae


Tarnoki, Adam Domonkos ; Tarnoki, David Laszlo ; Stazi, Maria Antonietta ; Medda, Emanuela ; Cotichini, Rodolfo ; Nisticò, Lorenza ; Fagnani, Corrado ; Lucatelli, Pierleone ; Boatta, Emanuele ; Zini, Chiara ; Fanelli, Fabrizio ; Baracchini, Claudio ; Meneghetti, Giorgio ; Osztovits, Janos ; Jermendy, Gyorgy ; Préda, István ; Kiss, Róbert Gábor ; Metneki, Julia ; Horvath, Tamas ; Karlinger, Kinga ; Racz, Adel ; Lannert, Agnes ; Molnar, Andrea Agnes ; Littvay, Levente ; Garami, Zsolt ; Berczi, Viktor ; Schillaci, Giuseppe. / Heritability of central blood pressure and arterial stiffness : A twin study. In: Journal of Hypertension. 2012 ; Vol. 30, No. 8. pp. 1564-1571.


title = "Heritability of central blood pressure and arterial stiffness: A twin study",
abstract = "Lippincott Williams & Wilkins.",
keywords = "augmentation index, environmental effects, genetics, pulse pressure, pulse wave velocity, twin study",
author = "Tarnoki, {Adam Domonkos} and Tarnoki, {David Laszlo} and Stazi, {Maria Antonietta} and Emanuela Medda and Rodolfo Cotichini and Lorenza Nistic{\`o} and Corrado Fagnani and Pierleone Lucatelli and Emanuele Boatta and Chiara Zini and Fabrizio Fanelli and Claudio Baracchini and Giorgio Meneghetti and Janos Osztovits and Gyorgy Jermendy and Istv{\'a}n Pr{\'e}da and Kiss, {R{\'o}bert G{\'a}bor} and Julia Metneki and Tamas Horvath and Kinga Karlinger and Adel Racz and Agnes Lannert and Molnar, {Andrea Agnes} and Levente Littvay and Zsolt Garami and Viktor Berczi and Giuseppe Schillaci",
year = "2012",
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language = "English",
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journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
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T1 - Heritability of central blood pressure and arterial stiffness

T2 - Journal of Hypertension

AU - Tarnoki, Adam Domonkos

AU - Tarnoki, David Laszlo

AU - Stazi, Maria Antonietta

AU - Medda, Emanuela

AU - Cotichini, Rodolfo

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AU - Fagnani, Corrado

AU - Lucatelli, Pierleone

AU - Boatta, Emanuele

AU - Zini, Chiara

AU - Fanelli, Fabrizio

AU - Baracchini, Claudio

AU - Meneghetti, Giorgio

AU - Osztovits, Janos

AU - Jermendy, Gyorgy

AU - Préda, István

AU - Kiss, Róbert Gábor

AU - Metneki, Julia

AU - Horvath, Tamas

AU - Karlinger, Kinga

AU - Racz, Adel

AU - Lannert, Agnes

AU - Molnar, Andrea Agnes

AU - Littvay, Levente

AU - Garami, Zsolt

AU - Berczi, Viktor

AU - Schillaci, Giuseppe

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KW - environmental effects

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