Heritability of arterial stiffness and carotid intima-media thickness: An Italian twin study

Research output: Contribution to journalArticle

E. Medda, C. Fagnani, G. Schillaci, A. D. Tarnoki, D. L. Tarnoki, C. Baracchini, G. Meneghetti, F. Fanelli, A. Alaeddin, G. Pucci, S. Alviti, R. Cotichini, S. Brescianini, E. Boatta, P. Lucatelli, L. Nisticò, L. Penna, M. Salemi, V. Toccaceli, C. Zini & 2 others Zsolt Garami, M. A. Stazi

Background and aims: Carotid intima-media thickness (IMT) and arterial stiffness parameters, including aortic augmentation index (AIx) and pulse wave velocity (PWV), are independent predictors of stroke and cardiovascular disease. Genetic effects on these traits were never explored in a Mediterranean country. The present study aims to quantify the contribution of genes, environment and age to carotid IMT and aortic Aix and PWV. Methods and results: The twin design was used. A total of 348 adult twins from the Italian Twin Register underwent measurements of carotid IMT and aortic PWV and AIx in three university hospitals located in Rome, Padua and Perugia. Carotid IMT was measured by B-mode ultrasound, aortic PWV and AIx by Arteriograph. Genetic modelling was performed to decompose total variance of traits into genetic, shared and unshared environmental and age components. For each phenotype, the best-fitting model included additive genetic, unshared environmental and age effects. For IMT, heritability was 0.32 (95% confidence interval (CI): 0.25-0.38), unshared environmental component was 0.25 (0.18-0.32) and age contribution was 0.44 (0.39-0.49). For AIx and PWV, heritabilities were 0.42 (0.29-0.55) and 0.49 (0.35-0.62), unshared environmental components were 0.31 (0.22-0.44) and 0.37 (0.26-0.51) and age contributions were 0.27 (0.16-0.39) and 0.14 (0.06-0.24), respectively. Conclusion: This study shows substantial genetic and unshared environmental influences on carotid intima-media thickness and arterial stiffness and confirms the relevant role of age in the aetiology of these traits. Further support is provided for prevention and health promotion strategies based on modifiable factors.

Original languageEnglish
Pages (from-to)511-517
Number of pages7
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume24
Issue number5
DOIs
StatePublished - Jan 1 2014

PMID: 24582685

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Heritability of arterial stiffness and carotid intima-media thickness : An Italian twin study. / Medda, E.; Fagnani, C.; Schillaci, G.; Tarnoki, A. D.; Tarnoki, D. L.; Baracchini, C.; Meneghetti, G.; Fanelli, F.; Alaeddin, A.; Pucci, G.; Alviti, S.; Cotichini, R.; Brescianini, S.; Boatta, E.; Lucatelli, P.; Nisticò, L.; Penna, L.; Salemi, M.; Toccaceli, V.; Zini, C.; Garami, Zsolt; Stazi, M. A.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 24, No. 5, 01.01.2014, p. 511-517.

Research output: Contribution to journalArticle

Harvard

Medda, E, Fagnani, C, Schillaci, G, Tarnoki, AD, Tarnoki, DL, Baracchini, C, Meneghetti, G, Fanelli, F, Alaeddin, A, Pucci, G, Alviti, S, Cotichini, R, Brescianini, S, Boatta, E, Lucatelli, P, Nisticò, L, Penna, L, Salemi, M, Toccaceli, V, Zini, C, Garami, Z & Stazi, MA 2014, 'Heritability of arterial stiffness and carotid intima-media thickness: An Italian twin study' Nutrition, Metabolism and Cardiovascular Diseases, vol. 24, no. 5, pp. 511-517. https://doi.org/10.1016/j.numecd.2013.10.031

APA

Medda, E., Fagnani, C., Schillaci, G., Tarnoki, A. D., Tarnoki, D. L., Baracchini, C., ... Stazi, M. A. (2014). Heritability of arterial stiffness and carotid intima-media thickness: An Italian twin study. Nutrition, Metabolism and Cardiovascular Diseases, 24(5), 511-517. https://doi.org/10.1016/j.numecd.2013.10.031

Vancouver

Medda E, Fagnani C, Schillaci G, Tarnoki AD, Tarnoki DL, Baracchini C et al. Heritability of arterial stiffness and carotid intima-media thickness: An Italian twin study. Nutrition, Metabolism and Cardiovascular Diseases. 2014 Jan 1;24(5):511-517. https://doi.org/10.1016/j.numecd.2013.10.031

Author

Medda, E. ; Fagnani, C. ; Schillaci, G. ; Tarnoki, A. D. ; Tarnoki, D. L. ; Baracchini, C. ; Meneghetti, G. ; Fanelli, F. ; Alaeddin, A. ; Pucci, G. ; Alviti, S. ; Cotichini, R. ; Brescianini, S. ; Boatta, E. ; Lucatelli, P. ; Nisticò, L. ; Penna, L. ; Salemi, M. ; Toccaceli, V. ; Zini, C. ; Garami, Zsolt ; Stazi, M. A. / Heritability of arterial stiffness and carotid intima-media thickness : An Italian twin study. In: Nutrition, Metabolism and Cardiovascular Diseases. 2014 ; Vol. 24, No. 5. pp. 511-517.

BibTeX

@article{d7230ecec7974d5880f1b6f131b25973,
title = "Heritability of arterial stiffness and carotid intima-media thickness: An Italian twin study",
abstract = "Background and aims: Carotid intima-media thickness (IMT) and arterial stiffness parameters, including aortic augmentation index (AIx) and pulse wave velocity (PWV), are independent predictors of stroke and cardiovascular disease. Genetic effects on these traits were never explored in a Mediterranean country. The present study aims to quantify the contribution of genes, environment and age to carotid IMT and aortic Aix and PWV. Methods and results: The twin design was used. A total of 348 adult twins from the Italian Twin Register underwent measurements of carotid IMT and aortic PWV and AIx in three university hospitals located in Rome, Padua and Perugia. Carotid IMT was measured by B-mode ultrasound, aortic PWV and AIx by Arteriograph. Genetic modelling was performed to decompose total variance of traits into genetic, shared and unshared environmental and age components. For each phenotype, the best-fitting model included additive genetic, unshared environmental and age effects. For IMT, heritability was 0.32 (95{\%} confidence interval (CI): 0.25-0.38), unshared environmental component was 0.25 (0.18-0.32) and age contribution was 0.44 (0.39-0.49). For AIx and PWV, heritabilities were 0.42 (0.29-0.55) and 0.49 (0.35-0.62), unshared environmental components were 0.31 (0.22-0.44) and 0.37 (0.26-0.51) and age contributions were 0.27 (0.16-0.39) and 0.14 (0.06-0.24), respectively. Conclusion: This study shows substantial genetic and unshared environmental influences on carotid intima-media thickness and arterial stiffness and confirms the relevant role of age in the aetiology of these traits. Further support is provided for prevention and health promotion strategies based on modifiable factors.",
keywords = "Augmentation index, Carotid thickness, Pulse wave velocity, Twin study",
author = "E. Medda and C. Fagnani and G. Schillaci and Tarnoki, {A. D.} and Tarnoki, {D. L.} and C. Baracchini and G. Meneghetti and F. Fanelli and A. Alaeddin and G. Pucci and S. Alviti and R. Cotichini and S. Brescianini and E. Boatta and P. Lucatelli and L. Nistic{\`o} and L. Penna and M. Salemi and V. Toccaceli and C. Zini and Zsolt Garami and Stazi, {M. A.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.numecd.2013.10.031",
language = "English",
volume = "24",
pages = "511--517",
journal = "Nutrition, Metabolism and Cardiovascular Diseases",
issn = "0939-4753",
publisher = "Elsevier",
number = "5",

}

RIS

TY - JOUR

T1 - Heritability of arterial stiffness and carotid intima-media thickness

T2 - Nutrition, Metabolism and Cardiovascular Diseases

AU - Medda, E.

AU - Fagnani, C.

AU - Schillaci, G.

AU - Tarnoki, A. D.

AU - Tarnoki, D. L.

AU - Baracchini, C.

AU - Meneghetti, G.

AU - Fanelli, F.

AU - Alaeddin, A.

AU - Pucci, G.

AU - Alviti, S.

AU - Cotichini, R.

AU - Brescianini, S.

AU - Boatta, E.

AU - Lucatelli, P.

AU - Nisticò, L.

AU - Penna, L.

AU - Salemi, M.

AU - Toccaceli, V.

AU - Zini, C.

AU - Garami, Zsolt

AU - Stazi, M. A.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background and aims: Carotid intima-media thickness (IMT) and arterial stiffness parameters, including aortic augmentation index (AIx) and pulse wave velocity (PWV), are independent predictors of stroke and cardiovascular disease. Genetic effects on these traits were never explored in a Mediterranean country. The present study aims to quantify the contribution of genes, environment and age to carotid IMT and aortic Aix and PWV. Methods and results: The twin design was used. A total of 348 adult twins from the Italian Twin Register underwent measurements of carotid IMT and aortic PWV and AIx in three university hospitals located in Rome, Padua and Perugia. Carotid IMT was measured by B-mode ultrasound, aortic PWV and AIx by Arteriograph. Genetic modelling was performed to decompose total variance of traits into genetic, shared and unshared environmental and age components. For each phenotype, the best-fitting model included additive genetic, unshared environmental and age effects. For IMT, heritability was 0.32 (95% confidence interval (CI): 0.25-0.38), unshared environmental component was 0.25 (0.18-0.32) and age contribution was 0.44 (0.39-0.49). For AIx and PWV, heritabilities were 0.42 (0.29-0.55) and 0.49 (0.35-0.62), unshared environmental components were 0.31 (0.22-0.44) and 0.37 (0.26-0.51) and age contributions were 0.27 (0.16-0.39) and 0.14 (0.06-0.24), respectively. Conclusion: This study shows substantial genetic and unshared environmental influences on carotid intima-media thickness and arterial stiffness and confirms the relevant role of age in the aetiology of these traits. Further support is provided for prevention and health promotion strategies based on modifiable factors.

AB - Background and aims: Carotid intima-media thickness (IMT) and arterial stiffness parameters, including aortic augmentation index (AIx) and pulse wave velocity (PWV), are independent predictors of stroke and cardiovascular disease. Genetic effects on these traits were never explored in a Mediterranean country. The present study aims to quantify the contribution of genes, environment and age to carotid IMT and aortic Aix and PWV. Methods and results: The twin design was used. A total of 348 adult twins from the Italian Twin Register underwent measurements of carotid IMT and aortic PWV and AIx in three university hospitals located in Rome, Padua and Perugia. Carotid IMT was measured by B-mode ultrasound, aortic PWV and AIx by Arteriograph. Genetic modelling was performed to decompose total variance of traits into genetic, shared and unshared environmental and age components. For each phenotype, the best-fitting model included additive genetic, unshared environmental and age effects. For IMT, heritability was 0.32 (95% confidence interval (CI): 0.25-0.38), unshared environmental component was 0.25 (0.18-0.32) and age contribution was 0.44 (0.39-0.49). For AIx and PWV, heritabilities were 0.42 (0.29-0.55) and 0.49 (0.35-0.62), unshared environmental components were 0.31 (0.22-0.44) and 0.37 (0.26-0.51) and age contributions were 0.27 (0.16-0.39) and 0.14 (0.06-0.24), respectively. Conclusion: This study shows substantial genetic and unshared environmental influences on carotid intima-media thickness and arterial stiffness and confirms the relevant role of age in the aetiology of these traits. Further support is provided for prevention and health promotion strategies based on modifiable factors.

KW - Augmentation index

KW - Carotid thickness

KW - Pulse wave velocity

KW - Twin study

UR - http://www.scopus.com/inward/record.url?scp=84899049189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899049189&partnerID=8YFLogxK

U2 - 10.1016/j.numecd.2013.10.031

DO - 10.1016/j.numecd.2013.10.031

M3 - Article

VL - 24

SP - 511

EP - 517

JO - Nutrition, Metabolism and Cardiovascular Diseases

JF - Nutrition, Metabolism and Cardiovascular Diseases

SN - 0939-4753

IS - 5

ER -

ID: 3345184