Hepatitis B virus genotypes in southwest Iran: Molecular, serological and clinical outcomes

Anahita Mojiri, Abbas Behzad-Behbahani, Mehdei Saberifirozi, Maryam Ardabili, Mahmood Beheshti, Marjan Rahsaz, Mehrdad Banihashemi, Negar Azarpira, Bita Geramizadeh, Baharak Khadang, Afsaneh Moaddeb, Mojgan Ghaedi, Tahereh Heidari, Ardeshir Torab, Alireza Salah, Saeid Amirzadeh, Zahra Jowkar, Davood Mehrabani, Samad Amini-Bavil-Olyaee, Mohammad Ali Dehyadegari

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Aim: To investigate the associations of hepatitis B virus (HBV) genotype with HBeAg and anti-HBe status, alanine aminotransferase (ALT) levels and HBV-DNA detection in different groups of HBV-infected patients in southwest Iran. Methods: A total of 89 HBsAg-positive serum samples were collected from the same number of patients. All sera were then investigated to determine HBV DNA and serological markers. For all the polymerase chain reaction (PCR)-positive samples, biochemical, histopathological assays and genotyping were also performed. Results: Genotype D was the only type of HBV found in different clinical forms of acute and chronic infections. There was a high prevalence of HBeAg-negative HBV-infected patients with chronic hepatitis (52.7%). Out of 55 patients with chronic hepatitis, seven (12.7%) were diagnosed with cirrhosis. A significant association between the presence of anti-HBe antibody and an increase in ALT level, among either HBeAg-negative (P = 0.01) or HBeAg-positive (P = 0.026) patients, was demonstrated. No significant differences were observed between the clinical outcomes of HBeAg-positive and-negative individuals (P = 0.24). Conclusion: Genotype D has been recognized as the only type of HBV found in different clinical forms of HBV infections, including cirrhosis, among the residents of southwest Iran. Anti-HBe possibly plays a role in disease progression in some patients with chronic hepatitis, at least for a period of disease.

Original languageEnglish (US)
Pages (from-to)1510-1513
Number of pages4
JournalWorld Journal of Gastroenterology
Volume14
Issue number10
DOIs
StatePublished - Mar 14 2008

Keywords

  • Anti-HBe
  • Cirrhosis
  • Hepatitis B virus-D
  • Iran
  • Polymerase chain reaction

ASJC Scopus subject areas

  • Gastroenterology

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