@article{5d0d2c698c0449d695892a7dbff08a9d,
title = "Hepatitis B immune globulin: Final report of a controlled, multicenter trial of efficacy in prevention of dialysis-associated hepatitis",
abstract = "In a randomized, double-blind multicenter trial, 284 patients and 282 staff members of renal dialysis units who lacked detectable hepatitis B surface antigen (HBsAg) and antibody to HBsAg (anti-HBs) were randomly assigned to receive two 3 ml injections of immune serum globulin with high, intermediate, or low titers of anti-HBs four months apart. The incidence of infection with hepatitis B and of development of HBsAg was significantly lower in both patients and staff who received the high-titer material than in subjects who received the low-titer preparation eight but not 12 months after randomization (P<0.01 for patients and P<0.04 for staff, low-titer vs. high-titer at eight months). The high-titer hepatitis B immune globulin preparation did not appear to affect the severity of the cases of hepatitis that did occur, the proportion of subjects who developed persistent antigenemia, or the magnitude or timing of primary anti-HBs responses.",
author = "Prince, {Alfred M.} and Wolf Szmuness and Mann, {Margaret K.} and Vyas, {Girish N.} and Grady, {George F.} and Shapiro, {Fred L.} and Suki, {Wadi N.} and Freidman, {Eli A.} and Avram, {Morell M.} and Stenzel, {Kurt H.}",
note = "Funding Information: Received for publication April 12, 1977, and in revised form August 26,1977. This study was supported by a contract from the Division of Blood Diseases and Resources, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland. We thank Dr. Robert H. Purcell for hepatitis A antibody determinations, Dr. Blaine Hollinger for determinations of antibody to hepatitis B core antigen, and Ms. Tommie Baker, Ms. Diana Daniels, Mr. Waverly Howard, Ms. Bessie Clinkscale, and Ms. Annie Mae Moffatt for technical assistance. The coordinating center for the study was the Laboratories of Virology and Epidemiology, The Lindsley F. Kimball Research Institute of The New York Blood Center. Dr. Alfred M. Prince was the principal investigator; Dr. Wolf Szmuness the epidemiologist; Ms. Margaret Mann the study coordinator; Ms. Gloria H. Block the consultant statistician; and Mr. Richard Levine, the computer programmer. The locations, participating medical workers, hospitals, and institutional affiliations of the collaborating centers are given in that order. San Francisco: Dr. Girish N. Vyas, Dr. Rudi Schmid, Dr. H. David Watts, and Ms. Linda Quisumbing; Mount Zion Hospital, San Francisco General Hospital, Mills Hospital, Herrick Hospital, Alta Bates Hospital, Franklin Hospital, El Camino Hospital, Sutter Hospital, Stanford Hospital, Parnassus Heights Hospital, and Providence Hospital; University of California Medical Center, Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",
year = "1978",
doi = "10.1093/infdis/137.2.131",
language = "English (US)",
volume = "137",
pages = "131--144",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "2",
}