Hepatitis B Immune Globulin: Effectiveness in Prevention of Dialysis-Associated Hepatitis

Alfred M. Prince, Wolf Szmuness, Margaret K. Mann, Girish N. Vyas, George F. Grady, Fred L. Shapiro, Wadi N. Suki, Eli A. Friedman, Kurt H. Stenzel

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


A randomized, double blind, multicenter study of hepatitis prevention by immune serum globulin with high anti-HBs titer (hepatitis B immune globulin) was carried out among 318 new patients and 296 staff members of renal dialysis units. Three milliliters of high titer globulin, repeated at 4 months, was compared with equal doses of intermediate or normal titer globulin. Among staff members, the cumulative percentages developing hepatitis or HBs Ag. or both, within 8 months were 6.9, 11.7, and 11.1 in the high, intermediate, and normal titer groups respecively. The lower incidence associated with high titer globulin was not significant (P<0.05). However, among the patients the respective percentages were 7.9, 21.3, and 23.1 and the lower incidence in the high titer globulin group was significant (P<0.01).

Original languageEnglish (US)
Pages (from-to)1063-1067
Number of pages5
JournalNew England Journal of Medicine
Issue number21
StatePublished - Nov 20 1975

ASJC Scopus subject areas

  • Medicine(all)


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