Heparin-coated balloon-expandable stent reduces intimal hyperplasia in the iliac artery in baboons

Peter H. Lin, Nicolas A. Chronos, Monique M. Marijianowski, Changyi Chen, Ruth L. Bush, Brian Conklin, Alan B. Lumsden, Stephen R. Hanson

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

PURPOSE: To examine the effect of heparin-coated balloon-expandable iliac stent placement on intimal hyperplasia in a baboon model. MATERIALS AND METHODS: Balloon-expandable (Palmaz-Schatz) stents were placed in bilateral common iliac arteries in 20 male baboons (mean weight: 8.8 kg). In each animal, a heparin-coated iliac stent was placed on one side and the contralateral iliac artery received an uncoated stent that served as a control. The iliac artery stents were harvested at 30 days (n = 10) and 90 days (n = 10). Arteriography was performed to assess iliac patency and intravascular ultrasonography was used to determine neointimal and luminal areas. Histologic and morphometric analysis and scanning electron microscopy were performed in the stent-implanted iliac arteries. RESULTS: One animal was excluded in the 30-day group because of premature death. In the remaining nine surviving animals, seven control stents (78%) and nine heparin-coated stents (100%) remained patent. Morphometric analysis showed that the iliac arteries with heparin-coated stents had larger luminal areas (17%, P < .05), less neointimal area (26%, P < .05), lower neointima-to-media ratios (32%, P < .05), and equivalent medial areas (P = .92) compared to the control group at 30 days. In contrast, all control and heparin-coated stents were patent (100%) in the 90-day group. In that group, the heparin-coated stent group had less neointimal area (28%, P < .05), lower neointima-to-media ratios (42%, P < .05), and equivalent medial area (P = .92) and luminal area (P = .07) compared to the control group. CONCLUSIONS: The data demonstrate that heparin-coated balloon-expandable stents reduce intimal hyperplasia after iliac artery stent placement. This approach may represent a useful strategy for prolonging luminal patency after iliac stent placement.

Original languageEnglish (US)
Pages (from-to)603-611
Number of pages9
JournalJournal of Vascular and Interventional Radiology
Volume14
Issue number5
DOIs
StatePublished - May 1 2003

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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