Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Sa Wang; Barbara A. Degar; Arthur Zieske; Nelofar Q. Shafi; Michal G. Rose

doi:10.1002/ajh.20202

Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Sa Wang, Barbara A. Degar, Arthur Zieske, Nelofar Q. Shafi, Michal G. Rose

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.

Original language	English (US)
Pages (from-to)	391-396
Number of pages	6
Journal	American Journal of Hematology
Volume	77
Issue number	4
DOIs	https://doi.org/10.1002/ajh.20202
State	Published - Dec 2004

Keywords

G-CSF
GM-CSF
Hemophagocytosis
Myelodysplasia
Splenectomy
Thrombophagocytosis

ASJC Scopus subject areas

Hematology

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10.1002/ajh.20202

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title = "Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia",

abstract = "We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.",

keywords = "G-CSF, GM-CSF, Hemophagocytosis, Myelodysplasia, Splenectomy, Thrombophagocytosis",

author = "Sa Wang and Degar, \{Barbara A.\} and Arthur Zieske and Shafi, \{Nelofar Q.\} and Rose, \{Michal G.\}",

year = "2004",

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AU - Wang, Sa

AU - Degar, Barbara A.

AU - Zieske, Arthur

AU - Shafi, Nelofar Q.

AU - Rose, Michal G.

PY - 2004/12

Y1 - 2004/12

N2 - We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.

AB - We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.

KW - G-CSF

KW - GM-CSF

KW - Hemophagocytosis

KW - Myelodysplasia

KW - Splenectomy

KW - Thrombophagocytosis

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JO - American Journal of Hematology

JF - American Journal of Hematology

IS - 4

ER -

Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Abstract

Keywords

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