Hemophagocytosis exacerbated by G-CSF/GM-CSF treatment in a patient with myelodysplasia

Sa Wang, Barbara A. Degar, Arthur Zieske, Nelofar Q. Shafi, Michal G. Rose

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

We describe a 75-year-old man with neutropenia in whom bone marrow aspirate and biopsy demonstrated hemophagocytosis associated with myelodysplasia (MDS). Therapy with granulocyte-colony stimulating factor (G-CSF) and granulocyte-monocyte-colony stimulating factor (GM-CSF) caused splenomegaly and severe thrombocytopenia, which recurred upon rechallenge. We propose that myeloid growth factors may be detrimental in patients with MDS-associated hemophagocytosis.

Original languageEnglish (US)
Pages (from-to)391-396
Number of pages6
JournalAmerican Journal of Hematology
Volume77
Issue number4
DOIs
StatePublished - Dec 2004

Keywords

  • G-CSF
  • GM-CSF
  • Hemophagocytosis
  • Myelodysplasia
  • Splenectomy
  • Thrombophagocytosis

ASJC Scopus subject areas

  • Hematology

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