Hemophagocytic syndrome after Kawasaki disease

Debra L. Palazzi, Kenneth L. McClain, Sheldon Kaplan

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Hemophagocytic syndrome (HPS) is a rare and life-threatening disease in which a generalized histiocytic proliferation results in hemophagocytosis and up-regulation of inflammatory cytokines. This syndrome has been associated with infections, malignancy, drugs and immunologic triggers such as Kawasaki disease (KD). We describe the clinical and laboratory features of two children with HPS after KD and review the three previously reported pediatric cases of recrudescence of KD leading to HPS.

Original languageEnglish (US)
Pages (from-to)663-666
Number of pages4
JournalPediatric Infectious Disease Journal
Issue number7
StatePublished - Jul 1 2003


  • Hemophagocytic syndrome
  • Kawasaki disease

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)


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