Hemodynamics of atherosclerotic mice

Craig J. Hartley, Anillcumar K. Reddy, Sridhar Madala, Baby Martin-McNult, Ronald Vergona, Mark E. Sullivan, Meredith Halks-Mille, George Taffet, Lloyd H. Michael, Mark L. Entman, Yi Xin Wmg

Research output: Contribution to journalArticle

Abstract

Apolipoprotein-E knockout mice are often used as models of human atherosclerosis, but little is known of the hemodynamic consequences. Using noninvasive Doppler methods, it was found that heart rate and blood pressure were normal but that aortic pulse wave velocity, mean aortic and mitral blood velocities, and peripheral wave reflections were increased. It was also demonstrated that heart weight/body weight ratio was increased, and that hematocrit was decreased. The changes are consistent with decreased peripheral vascular resistance and compliance and with volume overload cardiac hypertrophy.

Original languageEnglish (US)
Pages (from-to)2219-2222
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume3
DOIs
StatePublished - Jan 1 2000

Keywords

  • Atherosclerosis
  • Cardiac
  • Hemodynamics
  • Hypertrophy
  • Output
  • Ultrasonics

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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