Hemodynamics of atherosclerotic mice

Craig J. Hartley; Anillcumar K. Reddy; Sridhar Madala; Baby Martin-McNult; Ronald Vergona; Mark E. Sullivan; Meredith Halks-Mille; George Taffet; Lloyd H. Michael; Mark L. Entman; Yi Xin Wmg

doi:10.1109/IEMBS.2000.900578

Hemodynamics of atherosclerotic mice

Craig J. Hartley, Anillcumar K. Reddy, Sridhar Madala, Baby Martin-McNult, Ronald Vergona, Mark E. Sullivan, Meredith Halks-Mille, George Taffet, Lloyd H. Michael, Mark L. Entman, Yi Xin Wmg

Research output: Contribution to journal › Article › peer-review

Abstract

Apolipoprotein-E knockout mice are often used as models of human atherosclerosis, but little is known of the hemodynamic consequences. Using noninvasive Doppler methods, it was found that heart rate and blood pressure were normal but that aortic pulse wave velocity, mean aortic and mitral blood velocities, and peripheral wave reflections were increased. It was also demonstrated that heart weight/body weight ratio was increased, and that hematocrit was decreased. The changes are consistent with decreased peripheral vascular resistance and compliance and with volume overload cardiac hypertrophy.

Original language	English (US)
Pages (from-to)	2219-2222
Number of pages	4
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	3
DOIs	https://doi.org/10.1109/IEMBS.2000.900578
State	Published - 2000

Keywords

Atherosclerosis
Cardiac
Hemodynamics
Hypertrophy
Output
Ultrasonics

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

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10.1109/IEMBS.2000.900578

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title = "Hemodynamics of atherosclerotic mice",

abstract = "Apolipoprotein-E knockout mice are often used as models of human atherosclerosis, but little is known of the hemodynamic consequences. Using noninvasive Doppler methods, it was found that heart rate and blood pressure were normal but that aortic pulse wave velocity, mean aortic and mitral blood velocities, and peripheral wave reflections were increased. It was also demonstrated that heart weight/body weight ratio was increased, and that hematocrit was decreased. The changes are consistent with decreased peripheral vascular resistance and compliance and with volume overload cardiac hypertrophy.",

keywords = "Atherosclerosis, Cardiac, Hemodynamics, Hypertrophy, Output, Ultrasonics",

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doi = "10.1109/IEMBS.2000.900578",

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volume = "3",

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journal = "Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings",

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TY - JOUR

T1 - Hemodynamics of atherosclerotic mice

AU - Hartley, Craig J.

AU - Reddy, Anillcumar K.

AU - Madala, Sridhar

AU - Martin-McNult, Baby

AU - Vergona, Ronald

AU - Sullivan, Mark E.

AU - Halks-Mille, Meredith

AU - Taffet, George

AU - Michael, Lloyd H.

AU - Entman, Mark L.

AU - Wmg, Yi Xin

PY - 2000

Y1 - 2000

N2 - Apolipoprotein-E knockout mice are often used as models of human atherosclerosis, but little is known of the hemodynamic consequences. Using noninvasive Doppler methods, it was found that heart rate and blood pressure were normal but that aortic pulse wave velocity, mean aortic and mitral blood velocities, and peripheral wave reflections were increased. It was also demonstrated that heart weight/body weight ratio was increased, and that hematocrit was decreased. The changes are consistent with decreased peripheral vascular resistance and compliance and with volume overload cardiac hypertrophy.

AB - Apolipoprotein-E knockout mice are often used as models of human atherosclerosis, but little is known of the hemodynamic consequences. Using noninvasive Doppler methods, it was found that heart rate and blood pressure were normal but that aortic pulse wave velocity, mean aortic and mitral blood velocities, and peripheral wave reflections were increased. It was also demonstrated that heart weight/body weight ratio was increased, and that hematocrit was decreased. The changes are consistent with decreased peripheral vascular resistance and compliance and with volume overload cardiac hypertrophy.

KW - Atherosclerosis

KW - Cardiac

KW - Hemodynamics

KW - Hypertrophy

KW - Output

KW - Ultrasonics

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M3 - Article

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JO - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

JF - Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings

ER -

Hemodynamics of atherosclerotic mice

Abstract

Keywords

ASJC Scopus subject areas

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