Hemodynamically driven vein graft remodeling: A systems biology approach

Scott A. Berceli, Roger Tran-Son-Tay, Marc Garbey, Zhihua Jiang

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Despite intense investigation over several decades to understand the mechanisms of vein graft failure, few therapeutic modalities have emerged. Emphasis using standard reductionist approaches has been focused on cataloging the components involved in the early events following vein graft implantation, but limited insight has been gained in understanding the dynamic interaction of these components. We propose that the application of systems theory offers the opportunity for significant advances in this area. Focused on modeling the dynamic relationships that define living organisms, systems biology provides the necessary tools to further our understanding of the complex series of overlapping biologic events on surgical implantation of the vein graft. Through the use of ordinary differential equation and agent-based modeling techniques, we present our ongoing efforts to define the nonlinear interactions between hemodynamics and vascular adaptation.

Original languageEnglish (US)
Pages (from-to)S2-S9
JournalVascular
Volume17
Issue numberSUPPL. 1
DOIs
StatePublished - 2009

Keywords

  • Remodeling
  • Systems biology
  • Vein graft hemodynamics

ASJC Scopus subject areas

  • Surgery
  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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