Hemodynamic disturbance due to serial stenosis in human coronary bifurcations: a computational fluid dynamics study

Mauro Malvè, Gérard Finet, Manuel Lagache, Jacques Ohayon, Ricardo Coppel, Roderic I. Pettigrew

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Surgical treatment of coronary bifurcation in presence of two lesions is problematic due to postclinical complications. In recent years, fractional flow reserve has emerged as a valuable tool for assessing the functional severity of coronary stenosis in clinical practice. Numerical studies have facilitated prediction by idealized patient-specific biomechanical models. However, overall bifurcation hemodynamics in presence of stenotic lesions still needs to be better understood, to improve clinical intervention and reduce associated risks. In this chapter, we study the influence of serial stenotic coronary lesions on coronary blood flow, using a parametric model. Computational fluid dynamics simulations were carried out to characterize hemodynamic changes and fractional flow reserve according to various stenosis configurations and degrees of severity.

Original languageEnglish (US)
Title of host publicationBiomechanics of Coronary Atherosclerotic Plaque
Subtitle of host publicationFrom Model to Patient
PublisherElsevier
Pages225-250
Number of pages26
ISBN (Electronic)9780128171950
ISBN (Print)9780128171967
DOIs
StatePublished - Jan 1 2021

Keywords

  • Computational fluid dynamics
  • Double stenosis
  • Fractional flow reserve
  • Left coronary artery
  • Oscillatory shear index
  • Parametric coronary hemodynamics

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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