TY - JOUR
T1 - Hemodynamic assessment of partial mechanical circulatory support
T2 - data derived from computed tomography angiographic images and computational fluid dynamics
AU - Karmonik, Christof
AU - Partovi, Sasan
AU - Rengier, Fabian
AU - Meredig, Hagen
AU - Farag, Mina Berty
AU - Müller-Eschner, Matthias
AU - Arif, Rawa
AU - Popov, Aron-Frederik
AU - Kauczor, Hans-Ulrich
AU - Karck, Matthias
AU - Ruhparwar, Arjang
PY - 2015/4
Y1 - 2015/4
N2 - Partial mechanical circulatory support represents a new concept for the treatment of advanced heart failure. The Circulite Synergy Micro Pump(®), where the inflow cannula is connected to the left atrium and the outflow cannula to the right subclavian artery, was one of the first devices to introduce this concept to the clinic. Using computational fluid dynamics (CFD) simulations, hemodynamics in the aortic tree was visualized and quantified from computed tomography angiographic (CTA) images in two patients. A realistic computational model was created by integrating flow information from the native heart and from the Circulite device. Diastolic flow augmentation in the descending aorta but competing/antagonizing flow patterns in the proximal innominate artery was observed. Velocity time curves in the ascending aorta correlated well with those in the left common carotid, the left subclavian and the descending aorta but poorly with the one in the innominate. Our results demonstrate that CFD may be useful in providing a better understanding of the main flow patterns in mechanical circulatory support devices.
AB - Partial mechanical circulatory support represents a new concept for the treatment of advanced heart failure. The Circulite Synergy Micro Pump(®), where the inflow cannula is connected to the left atrium and the outflow cannula to the right subclavian artery, was one of the first devices to introduce this concept to the clinic. Using computational fluid dynamics (CFD) simulations, hemodynamics in the aortic tree was visualized and quantified from computed tomography angiographic (CTA) images in two patients. A realistic computational model was created by integrating flow information from the native heart and from the Circulite device. Diastolic flow augmentation in the descending aorta but competing/antagonizing flow patterns in the proximal innominate artery was observed. Velocity time curves in the ascending aorta correlated well with those in the left common carotid, the left subclavian and the descending aorta but poorly with the one in the innominate. Our results demonstrate that CFD may be useful in providing a better understanding of the main flow patterns in mechanical circulatory support devices.
U2 - 10.3978/j.issn.2223-3652.2015.03.03
DO - 10.3978/j.issn.2223-3652.2015.03.03
M3 - Article
C2 - 25984458
SN - 2223-3652
VL - 5
SP - 160
EP - 165
JO - Cardiovascular diagnosis and therapy
JF - Cardiovascular diagnosis and therapy
IS - 2
ER -