Hemocompatible Polyethylene Glycol Films on Silicon

Miqin Zhang, Mauro Ferrari

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

A simple hemocompatibility-enhancing technique for immobilizing a self-assembled polyethylene glycol multilayer onto silicon surfaces is introduced. It involves the functionalization of PEG by SiCl3 groups on its chain ends, and the reaction of the PEG organosilicon derivatives with hydroxylated groups on silicon surfaces. Surface properties of the treated surfaces were characterized by contact angle measurement, electron spectroscopy for chemical analysis, and ellipsometry. The coated PEG self-assembled molecular film showed effective suppression in both plasma protein adsorption and platelet adhesion to silicon surfaces.

Original languageEnglish (US)
Pages (from-to)81-89
Number of pages9
JournalBiomedical Microdevices
Volume1
Issue number1
DOIs
StatePublished - 1998

Keywords

  • ESCA
  • Hemocompatibility
  • PEG
  • Self-assembled
  • Silicon
  • Surface modification

ASJC Scopus subject areas

  • Genetics
  • Medicine (miscellaneous)
  • Neuroscience(all)

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