Hemocompatible Polyethylene Glycol Films on Silicon

Miqin Zhang; Mauro Ferrari

doi:10.1023/A:1009938507935

Hemocompatible Polyethylene Glycol Films on Silicon

Miqin Zhang, Mauro Ferrari

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

A simple hemocompatibility-enhancing technique for immobilizing a self-assembled polyethylene glycol multilayer onto silicon surfaces is introduced. It involves the functionalization of PEG by SiCl₃ groups on its chain ends, and the reaction of the PEG organosilicon derivatives with hydroxylated groups on silicon surfaces. Surface properties of the treated surfaces were characterized by contact angle measurement, electron spectroscopy for chemical analysis, and ellipsometry. The coated PEG self-assembled molecular film showed effective suppression in both plasma protein adsorption and platelet adhesion to silicon surfaces.

Original language	English (US)
Pages (from-to)	81-89
Number of pages	9
Journal	Biomedical Microdevices
Volume	1
Issue number	1
DOIs	https://doi.org/10.1023/A:1009938507935
State	Published - 1998

Keywords

ESCA
Hemocompatibility
PEG
Self-assembled
Silicon
Surface modification

ASJC Scopus subject areas

Genetics
Medicine (miscellaneous)
General Neuroscience

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title = "Hemocompatible Polyethylene Glycol Films on Silicon",

abstract = "A simple hemocompatibility-enhancing technique for immobilizing a self-assembled polyethylene glycol multilayer onto silicon surfaces is introduced. It involves the functionalization of PEG by SiCl3 groups on its chain ends, and the reaction of the PEG organosilicon derivatives with hydroxylated groups on silicon surfaces. Surface properties of the treated surfaces were characterized by contact angle measurement, electron spectroscopy for chemical analysis, and ellipsometry. The coated PEG self-assembled molecular film showed effective suppression in both plasma protein adsorption and platelet adhesion to silicon surfaces.",

keywords = "ESCA, Hemocompatibility, PEG, Self-assembled, Silicon, Surface modification",

author = "Miqin Zhang and Mauro Ferrari",

note = "Funding Information: Miqin Zhang wishes to thank the Department of Materials Science and Mineral Engineering of UC Berkeley for a doctoral fellowship.",

year = "1998",

doi = "10.1023/A:1009938507935",

language = "English (US)",

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T1 - Hemocompatible Polyethylene Glycol Films on Silicon

AU - Zhang, Miqin

AU - Ferrari, Mauro

N1 - Funding Information: Miqin Zhang wishes to thank the Department of Materials Science and Mineral Engineering of UC Berkeley for a doctoral fellowship.

PY - 1998

Y1 - 1998

N2 - A simple hemocompatibility-enhancing technique for immobilizing a self-assembled polyethylene glycol multilayer onto silicon surfaces is introduced. It involves the functionalization of PEG by SiCl3 groups on its chain ends, and the reaction of the PEG organosilicon derivatives with hydroxylated groups on silicon surfaces. Surface properties of the treated surfaces were characterized by contact angle measurement, electron spectroscopy for chemical analysis, and ellipsometry. The coated PEG self-assembled molecular film showed effective suppression in both plasma protein adsorption and platelet adhesion to silicon surfaces.

AB - A simple hemocompatibility-enhancing technique for immobilizing a self-assembled polyethylene glycol multilayer onto silicon surfaces is introduced. It involves the functionalization of PEG by SiCl3 groups on its chain ends, and the reaction of the PEG organosilicon derivatives with hydroxylated groups on silicon surfaces. Surface properties of the treated surfaces were characterized by contact angle measurement, electron spectroscopy for chemical analysis, and ellipsometry. The coated PEG self-assembled molecular film showed effective suppression in both plasma protein adsorption and platelet adhesion to silicon surfaces.

KW - ESCA

KW - Hemocompatibility

KW - PEG

KW - Self-assembled

KW - Silicon

KW - Surface modification

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Hemocompatible Polyethylene Glycol Films on Silicon

Abstract

Keywords

ASJC Scopus subject areas

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