Heme oxygenase-1: From bench to bedside

Danielle Morse, Augustine M.K. Choi

Research output: Contribution to journalReview article

154 Scopus citations

Abstract

As aspects of basic science come to play an increasingly prominent role in clinical medicine, heme oxygenase-1 is one of several molecules emerging as a central player in diseases of the lung and intensive care unit. Although the apparent raison d'être of this enzyme is to dispose of heme, its activity results in cytoprotection against oxidative injury and cellular stresses. As the lung interfaces directly with an oxidizing environment, it is expected that heme oxygenase-1 would be involved in many aspects of lung health and disease. The protective effects of heme oxygenase-1 and products of its enzymatic activity, including carbon monoxide, biliverdin and bilirubin, and ferritin, have opened the door to potential therapeutic and disease-monitoring possibilities that one day may be applicable to pulmonary medicine. This article introduces readers to the history of heme oxygenase research, the role of this enzyme in the lung, and related new developments to look forward to in the fields of pulmonary and critical care medicine.

Original languageEnglish (US)
Pages (from-to)660-670
Number of pages11
JournalAmerican journal of respiratory and critical care medicine
Volume172
Issue number6
DOIs
StatePublished - Sep 15 2005

Keywords

  • Carbon monoxide
  • Heme oxygenase-1
  • Lung
  • Nitric oxide

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine

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