Hematopoietic Stem Cell Transplantation for Multiple Myeloma: Guidelines from the American Society for Blood and Marrow Transplantation

Nina Shah, Natalie Callander, Siddhartha Ganguly, Zartash Gul, Mehdi Hamadani, Luciano Costa, Salyka Sengsayadeth, Muneer Abidi, Parameswaran Hari, Mohamad Mohty, Yi Bin Chen, John Koreth, Heather Landau, Hillard Lazarus, Helen Leather, Navneet Majhail, Rajneesh Nath, Keren Osman, Miguel Angel Perales, Jeffrey SchriberPaul Shaughnessy, David Vesole, Ravi Vij, John Wingard, Sergio Giralt, Bipin N. Savani

Research output: Contribution to journalReview articlepeer-review

80 Scopus citations

Abstract

Therapeutic strategies for multiple myeloma (MM) have changed dramatically over the past decade. Thus, the role of hematopoietic stem cell transplantation (HCT) must be considered in the context of this evolution. In this evidence-based review, we have critically analyzed the data from the most recent clinical trials to better understand how to incorporate HCT and when HCT is indicated. We have provided our recommendations based on strength of evidence with the knowledge that ongoing clinical trials make this a dynamic field. Within this document, we discuss the decision to proceed with autologous HCT, factors to consider before proceeding to HCT, the role of tandem autologous HCT, post-HCT maintenance therapy, and the role of allogeneic HCT for patients with MM.

Original languageEnglish (US)
Pages (from-to)1155-1166
Number of pages12
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Guidelines
  • Multiple myeloma
  • Recommendations
  • Transplantation

ASJC Scopus subject areas

  • Hematology
  • Transplantation

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