Hematological malignancies

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

The present cure rate for leukemia and lymphoma represents one of the success stories of modern cancer therapy. However, treatments remain toxic, expensive, and ineffective for many patients. There is therefore considerable interest in exploring gene therapies for these disorders. To date, four major strategies have been adopted: 1) modifying the tumor cell itself either by 'repairing' one or more genetic defect associated with the malignant process, introducing a gene that will trigger an anti-tumor immune response, or delivering a prodrug metabolizing enzyme that will render the tumor sensitive to the corresponding cytotoxic agent; 2) modifying the immune response to the tumor by altering the specificity or effector function of immune system cells; 3) decreasing the sensitivity of normal host tissue by delivering cytotoxic drug resistance genes to marrow precursor cells and thereby increasing the therapeutic index of cytotoxic agents; and 4) marking normal and malignant hemopoietic cells in order to more closely monitor the efficacy of conventional therapies. Given the current 'state of the art,' all these approaches have significant limitations, but each has had its successes, offering encouragement for future applications in clinical practice.

Original languageEnglish (US)
Pages (from-to)640-648
Number of pages9
JournalFASEB Journal
Volume11
Issue number8
DOIs
StatePublished - Jul 1997

Keywords

  • Bone marrow transplantation
  • Gene therapy
  • Gene transfer
  • Hemopoietic stem cell
  • Tumor vaccine

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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