Hematogenous pneumococcal meningitis in the infant rat: Description of a model

Adib F. Rodriguez, Sheldon L. Kaplan, Edith P. Hawkins, Edward O. Mason

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Sensorineural deafness occurs in 20%-30% of children after Streptococcus pneumoniae meningitis. An infant rat model of S. pneumoniae meningitis was developed to study the pathogenesis of inner ear invasion by S. pneumoniae. S. pneumoniae type 6 was administered intraperitoneally (inoculum: 1-10 × 108 cfu) every 24 h for 3 days to 5-day-old rats. Bacteremia (12 [50%] of 24) and meningitis (11 [46%] of 24) were detected most frequently 4 days after the three doses. The mean cerebrospinal fluid (CSF) white blood count for rats with positive CSF cultures was 7271/ mm3 (range, 81-20,475). Hematoxylin-eosin-stained brain tissue from the 11 rats with positive CSF cultures showed inflammation in the meninges and scala tympani in 9 each (82%), and scala vestibuli in 6 (55%), but none in the scala media. Gram's-stained brain and inner ear sections from the same 11 rats showed organisms in the meninges in 5 (45%) and scala tympani or vestibuli in 2 (18%). Perilymphatic inflammation occurred significantly (P < .001) more than did endolymphatic inflammation.

Original languageEnglish (US)
Pages (from-to)1207-1209
Number of pages3
JournalJournal of Infectious Diseases
Issue number6
StatePublished - Dec 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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