Heat shock proteins are important mediators of skeletal muscle insulin sensitivity

Paige C. Geiger, Anisha A. Gupte

    Research output: Contribution to journalArticlepeer-review

    50 Scopus citations

    Abstract

    Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.

    Original languageEnglish (US)
    Pages (from-to)34-42
    Number of pages9
    JournalExercise and Sport Sciences Reviews
    Volume39
    Issue number1
    DOIs
    StatePublished - Jan 2011

    Keywords

    • aging
    • glucose uptake
    • insulin signaling
    • mitochondria
    • obesity
    • oxidative stress
    • stress kinases

    ASJC Scopus subject areas

    • Orthopedics and Sports Medicine
    • Physical Therapy, Sports Therapy and Rehabilitation

    Fingerprint

    Dive into the research topics of 'Heat shock proteins are important mediators of skeletal muscle insulin sensitivity'. Together they form a unique fingerprint.

    Cite this