Heat shock proteins are important mediators of skeletal muscle insulin sensitivity

Paige C. Geiger, Anisha A. Gupte

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Endogenous heat shock proteins (HSP) are decreased in disease states associated with insulin resistance and aging. Induction of HSPs has been shown to decrease oxidative stress, inhibit inflammatory pathways, and enhance metabolic characteristics in skeletal muscle. As such, HSPs have the potential to function as an important defense system against the development of insulin resistance and type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)34-42
Number of pages9
JournalExercise and Sport Sciences Reviews
Volume39
Issue number1
DOIs
StatePublished - Jan 2011

Keywords

  • aging
  • glucose uptake
  • insulin signaling
  • mitochondria
  • obesity
  • oxidative stress
  • stress kinases

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

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