TY - JOUR
T1 - Heat shock protein 60 and cardiovascular diseases
T2 - An intricate love-hate story
AU - Krishnan-Sivadoss, Indumathi
AU - Mijares-Rojas, Iván A.
AU - Villarreal-Leal, Ramiro A.
AU - Torre-Amione, Guillermo
AU - Knowlton, Anne A.
AU - Guerrero-Beltrán, C. Enrique
N1 - Publisher Copyright:
© 2020 Wiley Periodicals LLC
PY - 2021/1
Y1 - 2021/1
N2 - Cardiovascular diseases (CVDs) are the result of complex pathophysiological processes in the tissues comprising the heart and blood vessels. Inflammation is the main culprit for the development of cardiovascular dysfunction, and it may be traced to cellular stress events including apoptosis, oxidative and shear stress, and cellular and humoral immune responses, all of which impair the system's structure and function. An intracellular chaperone, heat shock protein 60 (HSP60) is an intriguing example of a protein that may both be an ally and a foe for cardiovascular homeostasis; on one hand providing protection against cellular injury, and on the other triggering damaging responses through innate and adaptive immunity. In this review we will discuss the functions of HSP60 and its effects on cells and the immune system regulation, only to later address its implications in the development and progression of CVD. Lastly, we summarize the outcome of various studies targeting HSP60 as a potential therapeutic strategy for cardiovascular and other diseases.
AB - Cardiovascular diseases (CVDs) are the result of complex pathophysiological processes in the tissues comprising the heart and blood vessels. Inflammation is the main culprit for the development of cardiovascular dysfunction, and it may be traced to cellular stress events including apoptosis, oxidative and shear stress, and cellular and humoral immune responses, all of which impair the system's structure and function. An intracellular chaperone, heat shock protein 60 (HSP60) is an intriguing example of a protein that may both be an ally and a foe for cardiovascular homeostasis; on one hand providing protection against cellular injury, and on the other triggering damaging responses through innate and adaptive immunity. In this review we will discuss the functions of HSP60 and its effects on cells and the immune system regulation, only to later address its implications in the development and progression of CVD. Lastly, we summarize the outcome of various studies targeting HSP60 as a potential therapeutic strategy for cardiovascular and other diseases.
KW - heart diseases
KW - heart failure
KW - heat shock proteins
KW - immunity
KW - therapeutic
KW - Cardiovascular Diseases
KW - Chaperonin 60
KW - Immune System
KW - Humans
KW - Cardiovascular System
KW - Apoptosis
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U2 - 10.1002/med.21723
DO - 10.1002/med.21723
M3 - Review article
C2 - 32808366
AN - SCOPUS:85089473779
SN - 0198-6325
VL - 41
SP - 29
EP - 71
JO - Medicinal Research Reviews
JF - Medicinal Research Reviews
IS - 1
ER -