Heat-free photochemical tissue welding with 1,8-naphthalimide dyes using visible (420 nm) light

Millard M. Judy, James L. Matthews, Richard L. Boriak, A. Burlacu, Dorothy E. Lewis, et.al.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

22 Scopus citations

Abstract

We have newly designed and synthesized a class of photochemical 1,8-naphthalimide dyes. Photochemical investigation strongly suggests that these dyes function as photoalkylation agents following activation to an intermediate state by visible light (circa 420 nm) excitation. The activated species reacts readily with nucleophilic amino acid residues; e.g., tryptophan, tyrosine, cysteine, and methionine. One such dye, 1,14-bis(N-hexyl-3′-bromo- 1,8′-naphthalimid-4′-yl)-1,4,11,14-tetraazatetradecane-5,10-d ione, incorporating two reactive 1,8-naphthalimide groups at each end of an intervening structural bridge has been used to achieve photochemical or photoactivated bonding (welding) of collagenous dura mater sheets to each other. Weld shear strengths of up to 425 gm/cm2 (1.14 × 104 Nt/m2) have been obtained.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherPubl by Society of Photo-Optical Instrumentation Engineers
Pages175-179
Number of pages5
ISBN (Print)0819411035, 9780819411037
DOIs
StatePublished - 1993
EventLasers in Otolaryngology, Dermatology, and Tissue Welding - Los Angeles, CA, USA
Duration: Jan 16 1993Jan 18 1993

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume1876
ISSN (Print)0277-786X

Other

OtherLasers in Otolaryngology, Dermatology, and Tissue Welding
CityLos Angeles, CA, USA
Period1/16/931/18/93

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

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