Heart valves from polyester fibers: A preliminary 6-month in vivo study

Antoine Vaesken, Anne Pelle, Graciela Pavon-Djavid, Jeanne Rancic, Nabil Chakfe, Frederic Heim

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Transcatheter aortic valve implantation (TAVI) has become a popular alternative technique to surgical valve replacement for critical patients. Biological valve tissue has been used in TAVI procedures for over a decade, with over 150,000 implantations to date. However, with only 6 years of follow up, little is known about the long-term durability of biological tissue. Moreover, the high cost of tissue harvesting and chemical treatment procedures favor the development of alternative synthetic valve leaflet materials. In that context, textile polyester [polyethylene terephthalate (PET)] could be considered as an interesting candidate to replace the biological valve leaflets in TAVI procedures. However, no result is available in the literature about the behavior of textile once in contact with biological tissue in the valve position. The interaction of synthetic textile material with living tissues should be comparable to biological tissue. The purpose of this preliminary work is to compare the in vivo performances of various woven textile PET valves over a 6-month period in order to identify favorable textile construction features. In vivo results indicate that fibrosis as well as calcium deposit can be limited with an appropriate material design.

Original languageEnglish (US)
Pages (from-to)271-278
Number of pages8
JournalBiomedizinische Technik
Volume63
Issue number3
DOIs
StatePublished - Jun 27 2018

Keywords

  • TAVI
  • fiber valve
  • heart valve
  • textile valve
  • transcatheter valve
  • valve fibrosis

ASJC Scopus subject areas

  • Biomedical Engineering

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