Health status and patient-reported osteoarthritis severity in clinical practice

Joseph C. Cappelleri, Andrew G. Bushmakin, Alesia B. Sadosky, David R. Lionberger, Jr.

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Aim: To determine how patient-reported osteoarthritis (OA) severity relates to patient-reported health status and physician-rated outcomes in clinical practice. Methods: Data were derived from the U.S.-based sample of the 2008 Adelphi Disease Specific Programme for OA (OA DSP VII). Patients self-rated their OA severity as "mild," "moderate," and "severe." The association of OA severity with patientreported health status (EQ-5D) and physician-completed health assessments was evaluated using regression models for quantitative variables (adjusted for age and gender, with patient-reported OA severity as the predictor) and chi-square tests for qualitative variables. Results: Of 998 subjects in the OA DSP VII, 714 (71.5%) agreed to participate. The population was predominantly female (61.7%) with a mean age of 63.8 years, and a mean of 5.6 years since OA diagnosis. Patient-reported OA severity was significantly associated (p<0.01) with health status on all 5 EQ-5D dimensions (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression). The EQ-5D preferenceweighted index, based on U.S. preference values, decreased with increasing OA severity (mild, 0.85; moderate, 0.73; severe, 0.52; all pairwise comparisons p<0.001). Patientreported OA severity was associated with increased levels of analgesia requirements (p<0.05) and with the presence of cardiovascular (p<0.001) and gastric conditions (p<0.001). Although there was a significant association between patient-and physician- reported OA severity (p<0.05), physicians generally overrated mild OA and underrated severe OA relative to patients. Conclusions: In the clinical setting, patient-reported OA severity offers a rapid and useful assessment that maps to a key measure of health status, suggesting applicability to guiding patient management strategies.

Original languageEnglish (US)
Title of host publicationFunctional Impairment
Subtitle of host publicationManagement, Types and Challenges
PublisherNova Science Publishers, Inc.
Pages15-27
Number of pages13
ISBN (Print)9781620814109
StatePublished - Oct 1 2012

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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