TY - JOUR
T1 - Health position paper and redox perspectives - Disease burden by transportation noise
AU - Sørensen, Mette
AU - Pershagen, Göran
AU - Thacher, Jesse Daniel
AU - Lanki, Timo
AU - Wicki, Benedikt
AU - Röösli, Martin
AU - Vienneau, Danielle
AU - Cantuaria, Manuella Lech
AU - Schmidt, Jesper Hvass
AU - Aasvang, Gunn Marit
AU - Al-Kindi, Sadeer
AU - Osborne, Michael T.
AU - Wenzel, Philip
AU - Sastre, Juan
AU - Fleming, Ingrid
AU - Schulz, Rainer
AU - Hahad, Omar
AU - Kuntic, Marin
AU - Zielonka, Jacek
AU - Sies, Helmut
AU - Grune, Tilman
AU - Frenis, Katie
AU - Münzel, Thomas
AU - Daiber, Andreas
N1 - Copyright © 2023 Elsevier B.V. All rights reserved.
PY - 2024/2
Y1 - 2024/2
N2 - Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence for a link to other diseases was very low to moderate. Since then, several studies on the impact of noise on various diseases have been published. Also, studies investigating the mechanistic pathways underlying noise-induced health effects are emerging. We review the current evidence regarding effects of noise on health and the related disease-mechanisms. Several high-quality cohort studies consistently found road traffic noise to be associated with a higher risk of ischemic heart disease, heart failure, diabetes, and all-cause mortality. Furthermore, recent studies have indicated that road traffic and railway noise may increase the risk of diseases not commonly investigated in an environmental noise context, including breast cancer, dementia, and tinnitus. The harmful effects of noise are related to activation of a physiological stress response and nighttime sleep disturbance. Oxidative stress and inflammation downstream of stress hormone signaling and dysregulated circadian rhythms are identified as major disease-relevant pathomechanistic drivers. We discuss the role of reactive oxygen species and present results from antioxidant interventions. Lastly, we provide an overview of oxidative stress markers and adverse redox processes reported for noise-exposed animals and humans. This position paper summarizes all available epidemiological, clinical, and preclinical evidence of transportation noise as an important environmental risk factor for public health and discusses its implications on the population level.
AB - Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence for a link to other diseases was very low to moderate. Since then, several studies on the impact of noise on various diseases have been published. Also, studies investigating the mechanistic pathways underlying noise-induced health effects are emerging. We review the current evidence regarding effects of noise on health and the related disease-mechanisms. Several high-quality cohort studies consistently found road traffic noise to be associated with a higher risk of ischemic heart disease, heart failure, diabetes, and all-cause mortality. Furthermore, recent studies have indicated that road traffic and railway noise may increase the risk of diseases not commonly investigated in an environmental noise context, including breast cancer, dementia, and tinnitus. The harmful effects of noise are related to activation of a physiological stress response and nighttime sleep disturbance. Oxidative stress and inflammation downstream of stress hormone signaling and dysregulated circadian rhythms are identified as major disease-relevant pathomechanistic drivers. We discuss the role of reactive oxygen species and present results from antioxidant interventions. Lastly, we provide an overview of oxidative stress markers and adverse redox processes reported for noise-exposed animals and humans. This position paper summarizes all available epidemiological, clinical, and preclinical evidence of transportation noise as an important environmental risk factor for public health and discusses its implications on the population level.
KW - Adverse redox signaling
KW - Environmental risk factors
KW - Non-communicable diseases
KW - Oxidative stress and inflammation
KW - Stress hormones
KW - Transportation noise
KW - Oxidation-Reduction
KW - Noise, Transportation/adverse effects
KW - Humans
KW - Myocardial Ischemia
KW - Animals
KW - Environmental Exposure/adverse effects
KW - Cohort Studies
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U2 - 10.1016/j.redox.2023.102995
DO - 10.1016/j.redox.2023.102995
M3 - Review article
C2 - 38142584
AN - SCOPUS:85180606610
SN - 2213-2317
VL - 69
SP - 102995
JO - Redox Biology
JF - Redox Biology
M1 - 102995
ER -