Health position paper and redox perspectives - Disease burden by transportation noise

Mette Sørensen, Göran Pershagen, Jesse Daniel Thacher, Timo Lanki, Benedikt Wicki, Martin Röösli, Danielle Vienneau, Manuella Lech Cantuaria, Jesper Hvass Schmidt, Gunn Marit Aasvang, Sadeer Al-Kindi, Michael T. Osborne, Philip Wenzel, Juan Sastre, Ingrid Fleming, Rainer Schulz, Omar Hahad, Marin Kuntic, Jacek Zielonka, Helmut SiesTilman Grune, Katie Frenis, Thomas Münzel, Andreas Daiber

Research output: Contribution to journalReview articlepeer-review

15 Scopus citations

Abstract

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence for a link to other diseases was very low to moderate. Since then, several studies on the impact of noise on various diseases have been published. Also, studies investigating the mechanistic pathways underlying noise-induced health effects are emerging. We review the current evidence regarding effects of noise on health and the related disease-mechanisms. Several high-quality cohort studies consistently found road traffic noise to be associated with a higher risk of ischemic heart disease, heart failure, diabetes, and all-cause mortality. Furthermore, recent studies have indicated that road traffic and railway noise may increase the risk of diseases not commonly investigated in an environmental noise context, including breast cancer, dementia, and tinnitus. The harmful effects of noise are related to activation of a physiological stress response and nighttime sleep disturbance. Oxidative stress and inflammation downstream of stress hormone signaling and dysregulated circadian rhythms are identified as major disease-relevant pathomechanistic drivers. We discuss the role of reactive oxygen species and present results from antioxidant interventions. Lastly, we provide an overview of oxidative stress markers and adverse redox processes reported for noise-exposed animals and humans. This position paper summarizes all available epidemiological, clinical, and preclinical evidence of transportation noise as an important environmental risk factor for public health and discusses its implications on the population level.

Original languageEnglish (US)
Article number102995
Pages (from-to)102995
JournalRedox Biology
Volume69
DOIs
StatePublished - Feb 2024

Keywords

  • Adverse redox signaling
  • Environmental risk factors
  • Non-communicable diseases
  • Oxidative stress and inflammation
  • Stress hormones
  • Transportation noise
  • Oxidation-Reduction
  • Noise, Transportation/adverse effects
  • Humans
  • Myocardial Ischemia
  • Animals
  • Environmental Exposure/adverse effects
  • Cohort Studies

ASJC Scopus subject areas

  • Organic Chemistry

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