Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair

Stewart A. Low; Chris V. Galliford; Yava L. Jones-Hall; Jyoti Roy; Jiyuan Yang; Philip S. Low; Jindřich Kopeček

doi:10.2217/nnm-2016-0340

Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair

Stewart A. Low, Chris V. Galliford, Yava L. Jones-Hall, Jyoti Roy, Jiyuan Yang, Philip S. Low, Jindřich Kopeček

Houston Methodist

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Aim: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3′-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. Materials & methods: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing.Results: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues. Conclusion: Accelerated fracture healing in mice was achieved by targeting the GSK3β inhibitor, 6-bromoindirubin-3′-oxime, to the fracture site.

Original language	English (US)
Pages (from-to)	185-193
Number of pages	9
Journal	Nanomedicine
Volume	12
Issue number	3
DOIs	https://doi.org/10.2217/nnm-2016-0340
State	Published - Feb 2017

Keywords

bone targeting
fracture healing
micelles

ASJC Scopus subject areas

Bioengineering
Development
General Materials Science
Biomedical Engineering
Medicine (miscellaneous)

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10.2217/nnm-2016-0340

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title = "Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair",

abstract = "Aim: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3′-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. Materials & methods: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing.Results: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues. Conclusion: Accelerated fracture healing in mice was achieved by targeting the GSK3β inhibitor, 6-bromoindirubin-3′-oxime, to the fracture site.",

keywords = "bone targeting, fracture healing, micelles",

author = "Low, {Stewart A.} and Galliford, {Chris V.} and Jones-Hall, {Yava L.} and Jyoti Roy and Jiyuan Yang and Low, {Philip S.} and Jind{\v r}ich Kope{\v c}ek",

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doi = "10.2217/nnm-2016-0340",

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AU - Low, Stewart A.

AU - Galliford, Chris V.

AU - Jones-Hall, Yava L.

AU - Roy, Jyoti

AU - Yang, Jiyuan

AU - Low, Philip S.

AU - Kopeček, Jindřich

PY - 2017/2

Y1 - 2017/2

N2 - Aim: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3′-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. Materials & methods: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing.Results: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues. Conclusion: Accelerated fracture healing in mice was achieved by targeting the GSK3β inhibitor, 6-bromoindirubin-3′-oxime, to the fracture site.

AB - Aim: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3′-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. Materials & methods: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing.Results: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues. Conclusion: Accelerated fracture healing in mice was achieved by targeting the GSK3β inhibitor, 6-bromoindirubin-3′-oxime, to the fracture site.

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KW - fracture healing

KW - micelles

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Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair

Abstract

Keywords

ASJC Scopus subject areas

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