Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair

Stewart A. Low, Chris V. Galliford, Yava L. Jones-Hall, Jyoti Roy, Jiyuan Yang, Philip S. Low, Jindřich Kopeček

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Aim: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3′-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system. Materials & methods: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing.Results: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues. Conclusion: Accelerated fracture healing in mice was achieved by targeting the GSK3β inhibitor, 6-bromoindirubin-3′-oxime, to the fracture site.

Original languageEnglish (US)
Pages (from-to)185-193
Number of pages9
JournalNanomedicine
Volume12
Issue number3
DOIs
StatePublished - Feb 2017

Keywords

  • bone targeting
  • fracture healing
  • micelles

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

Fingerprint Dive into the research topics of 'Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair'. Together they form a unique fingerprint.

Cite this