Head and neck tuberculosis: Literature review and meta-analysis

Research output: Contribution to journalArticle

Xu Qian, Andreas E Albers, Duc T M Nguyen, Yue Dong, Yuping Zhang, Frank Schreiber, Branko Sinikovic, Xiaohong Bi, Edward A Graviss

BACKGROUND: Head and neck tuberculosis (HNTB), including cervical lymphadenopathy, is the most common extrapulmonary manifestation of TB. The proposed study investigated the epidemiologic and clinical characteristics of HNTB.

MATERIALS AND METHODS: A literature search was conducted via PubMed, Embase, Cochrane Library and Wanfang for keywords (tuberculosis, head and neck, laryngeal, pharyngeal, tongue, oropharyngeal, nasopharyngeal, and oral cavity). Scientific articles published from January 1990 through July 2017 were selected and reviewed to assess the epidemiology, presentation, diagnosis and treatment of HNTB disease.

RESULTS: Results from the included 57 studies revealed that the majority of HNTB cases were age<40 years and female. The most common HNTB sites were cervical lymph nodes (87.9%), followed by larynx (8.7%). Involvement of other HN-regions was rare (3.4%). Multidrug resistant TB was not common among the majority of studies. Given the paucibacillary nature of HNTB, sputum tests did not have a good performance on HNTB diagnosis. Most of HNTB cases were diagnosed by fine-needle aspiration, cytology and excision biopsies in combination with clinical presentations.

CONCLUSION: HNTB disease is an important manifestation in the diagnostic process in an otolaryngologist practice. The developments of rapid, ultrasensitive, simple and cost-effective high-throughput methods for early diagnosis of HNTB are urgently needed.

Original languageEnglish (US)
JournalTuberculosis
DOIs
StateE-pub ahead of print - May 3 2019

PMID: 31080090

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Head and neck tuberculosis : Literature review and meta-analysis. / Qian, Xu; Albers, Andreas E; Nguyen, Duc T M; Dong, Yue; Zhang, Yuping; Schreiber, Frank; Sinikovic, Branko; Bi, Xiaohong; Graviss, Edward A.

In: Tuberculosis, 03.05.2019.

Research output: Contribution to journalArticle

Harvard

Qian, X, Albers, AE, Nguyen, DTM, Dong, Y, Zhang, Y, Schreiber, F, Sinikovic, B, Bi, X & Graviss, EA 2019, 'Head and neck tuberculosis: Literature review and meta-analysis' Tuberculosis. https://doi.org/10.1016/j.tube.2019.04.014

APA

Qian, X., Albers, A. E., Nguyen, D. T. M., Dong, Y., Zhang, Y., Schreiber, F., ... Graviss, E. A. (2019). Head and neck tuberculosis: Literature review and meta-analysis. Tuberculosis. https://doi.org/10.1016/j.tube.2019.04.014

Vancouver

Qian X, Albers AE, Nguyen DTM, Dong Y, Zhang Y, Schreiber F et al. Head and neck tuberculosis: Literature review and meta-analysis. Tuberculosis. 2019 May 3. https://doi.org/10.1016/j.tube.2019.04.014

Author

Qian, Xu ; Albers, Andreas E ; Nguyen, Duc T M ; Dong, Yue ; Zhang, Yuping ; Schreiber, Frank ; Sinikovic, Branko ; Bi, Xiaohong ; Graviss, Edward A. / Head and neck tuberculosis : Literature review and meta-analysis. In: Tuberculosis. 2019.

BibTeX

@article{30b6d882bd0c42f9b620e5c4d9b0d202,
title = "Head and neck tuberculosis: Literature review and meta-analysis",
abstract = "BACKGROUND: Head and neck tuberculosis (HNTB), including cervical lymphadenopathy, is the most common extrapulmonary manifestation of TB. The proposed study investigated the epidemiologic and clinical characteristics of HNTB.MATERIALS AND METHODS: A literature search was conducted via PubMed, Embase, Cochrane Library and Wanfang for keywords (tuberculosis, head and neck, laryngeal, pharyngeal, tongue, oropharyngeal, nasopharyngeal, and oral cavity). Scientific articles published from January 1990 through July 2017 were selected and reviewed to assess the epidemiology, presentation, diagnosis and treatment of HNTB disease.RESULTS: Results from the included 57 studies revealed that the majority of HNTB cases were age<40 years and female. The most common HNTB sites were cervical lymph nodes (87.9{\%}), followed by larynx (8.7{\%}). Involvement of other HN-regions was rare (3.4{\%}). Multidrug resistant TB was not common among the majority of studies. Given the paucibacillary nature of HNTB, sputum tests did not have a good performance on HNTB diagnosis. Most of HNTB cases were diagnosed by fine-needle aspiration, cytology and excision biopsies in combination with clinical presentations.CONCLUSION: HNTB disease is an important manifestation in the diagnostic process in an otolaryngologist practice. The developments of rapid, ultrasensitive, simple and cost-effective high-throughput methods for early diagnosis of HNTB are urgently needed.",
author = "Xu Qian and Albers, {Andreas E} and Nguyen, {Duc T M} and Yue Dong and Yuping Zhang and Frank Schreiber and Branko Sinikovic and Xiaohong Bi and Graviss, {Edward A}",
note = "Copyright {\circledC} 2019 Elsevier Ltd. All rights reserved.",
year = "2019",
month = "5",
day = "3",
doi = "10.1016/j.tube.2019.04.014",
language = "English (US)",
journal = "Tuberculosis",
issn = "1472-9792",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Head and neck tuberculosis

T2 - Tuberculosis

AU - Qian, Xu

AU - Albers, Andreas E

AU - Nguyen, Duc T M

AU - Dong, Yue

AU - Zhang, Yuping

AU - Schreiber, Frank

AU - Sinikovic, Branko

AU - Bi, Xiaohong

AU - Graviss, Edward A

N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.

PY - 2019/5/3

Y1 - 2019/5/3

N2 - BACKGROUND: Head and neck tuberculosis (HNTB), including cervical lymphadenopathy, is the most common extrapulmonary manifestation of TB. The proposed study investigated the epidemiologic and clinical characteristics of HNTB.MATERIALS AND METHODS: A literature search was conducted via PubMed, Embase, Cochrane Library and Wanfang for keywords (tuberculosis, head and neck, laryngeal, pharyngeal, tongue, oropharyngeal, nasopharyngeal, and oral cavity). Scientific articles published from January 1990 through July 2017 were selected and reviewed to assess the epidemiology, presentation, diagnosis and treatment of HNTB disease.RESULTS: Results from the included 57 studies revealed that the majority of HNTB cases were age<40 years and female. The most common HNTB sites were cervical lymph nodes (87.9%), followed by larynx (8.7%). Involvement of other HN-regions was rare (3.4%). Multidrug resistant TB was not common among the majority of studies. Given the paucibacillary nature of HNTB, sputum tests did not have a good performance on HNTB diagnosis. Most of HNTB cases were diagnosed by fine-needle aspiration, cytology and excision biopsies in combination with clinical presentations.CONCLUSION: HNTB disease is an important manifestation in the diagnostic process in an otolaryngologist practice. The developments of rapid, ultrasensitive, simple and cost-effective high-throughput methods for early diagnosis of HNTB are urgently needed.

AB - BACKGROUND: Head and neck tuberculosis (HNTB), including cervical lymphadenopathy, is the most common extrapulmonary manifestation of TB. The proposed study investigated the epidemiologic and clinical characteristics of HNTB.MATERIALS AND METHODS: A literature search was conducted via PubMed, Embase, Cochrane Library and Wanfang for keywords (tuberculosis, head and neck, laryngeal, pharyngeal, tongue, oropharyngeal, nasopharyngeal, and oral cavity). Scientific articles published from January 1990 through July 2017 were selected and reviewed to assess the epidemiology, presentation, diagnosis and treatment of HNTB disease.RESULTS: Results from the included 57 studies revealed that the majority of HNTB cases were age<40 years and female. The most common HNTB sites were cervical lymph nodes (87.9%), followed by larynx (8.7%). Involvement of other HN-regions was rare (3.4%). Multidrug resistant TB was not common among the majority of studies. Given the paucibacillary nature of HNTB, sputum tests did not have a good performance on HNTB diagnosis. Most of HNTB cases were diagnosed by fine-needle aspiration, cytology and excision biopsies in combination with clinical presentations.CONCLUSION: HNTB disease is an important manifestation in the diagnostic process in an otolaryngologist practice. The developments of rapid, ultrasensitive, simple and cost-effective high-throughput methods for early diagnosis of HNTB are urgently needed.

U2 - 10.1016/j.tube.2019.04.014

DO - 10.1016/j.tube.2019.04.014

M3 - Article

JO - Tuberculosis

JF - Tuberculosis

SN - 1472-9792

ER -

ID: 48347656