HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells

Research output: Contribution to journalArticle

Marcos Quintela, Douglas H. Sieglaff, Andrea Salvatore Gazze, Aijun Zhang, Deyarina Gonzalez, Lewis Francis, Paul Webb, R. Steven Conlan

New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone acetyltransferase HBO1 functions in regulating diverse molecular processes, including DNA repair, transcription and replication, and is highly expressed in primary ovarian cancer. Here we define both the molecular function and a role in cell biomechanics for HBO1 in ovarian cancer. HBO1 preferentially acetylates histone H4 through the concomitant overexpression of co-regulator JADE2, and is required for the expression of YAP1, an ovarian cancer oncogene and mechano-transductor signaling factor. HBO1 appears therefore to have a role in determining the mechano-phenotype in ovarian cancer cells, through both signal transduction processes, and the modulation of cell elasticity as observed using direct measurements on live cells via atomic force microscopy.

Original languageEnglish (US)
Pages (from-to)254-265
Number of pages12
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume17
DOIs
StatePublished - Apr 1 2019

PMID: 30759370

Altmetrics

Cite this

Standard

HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. / Quintela, Marcos; Sieglaff, Douglas H.; Gazze, Andrea Salvatore; Zhang, Aijun; Gonzalez, Deyarina; Francis, Lewis; Webb, Paul; Conlan, R. Steven.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 17, 01.04.2019, p. 254-265.

Research output: Contribution to journalArticle

Harvard

Quintela, M, Sieglaff, DH, Gazze, AS, Zhang, A, Gonzalez, D, Francis, L, Webb, P & Conlan, RS 2019, 'HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells' Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 17, pp. 254-265. https://doi.org/10.1016/j.nano.2019.01.017

APA

Quintela, M., Sieglaff, D. H., Gazze, A. S., Zhang, A., Gonzalez, D., Francis, L., ... Conlan, R. S. (2019). HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine: Nanotechnology, Biology, and Medicine, 17, 254-265. https://doi.org/10.1016/j.nano.2019.01.017

Vancouver

Quintela M, Sieglaff DH, Gazze AS, Zhang A, Gonzalez D, Francis L et al. HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. Nanomedicine: Nanotechnology, Biology, and Medicine. 2019 Apr 1;17:254-265. https://doi.org/10.1016/j.nano.2019.01.017

Author

Quintela, Marcos ; Sieglaff, Douglas H. ; Gazze, Andrea Salvatore ; Zhang, Aijun ; Gonzalez, Deyarina ; Francis, Lewis ; Webb, Paul ; Conlan, R. Steven. / HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2019 ; Vol. 17. pp. 254-265.

BibTeX

@article{d28985eee9824395a4f0185c6ef97b6a,
title = "HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells",
abstract = "New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone acetyltransferase HBO1 functions in regulating diverse molecular processes, including DNA repair, transcription and replication, and is highly expressed in primary ovarian cancer. Here we define both the molecular function and a role in cell biomechanics for HBO1 in ovarian cancer. HBO1 preferentially acetylates histone H4 through the concomitant overexpression of co-regulator JADE2, and is required for the expression of YAP1, an ovarian cancer oncogene and mechano-transductor signaling factor. HBO1 appears therefore to have a role in determining the mechano-phenotype in ovarian cancer cells, through both signal transduction processes, and the modulation of cell elasticity as observed using direct measurements on live cells via atomic force microscopy.",
keywords = "Acetyltransferase, Biomechanics, Elasticity, JADE, YAP1",
author = "Marcos Quintela and Sieglaff, {Douglas H.} and Gazze, {Andrea Salvatore} and Aijun Zhang and Deyarina Gonzalez and Lewis Francis and Paul Webb and Conlan, {R. Steven}",
year = "2019",
month = "4",
day = "1",
doi = "10.1016/j.nano.2019.01.017",
language = "English (US)",
volume = "17",
pages = "254--265",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells

AU - Quintela, Marcos

AU - Sieglaff, Douglas H.

AU - Gazze, Andrea Salvatore

AU - Zhang, Aijun

AU - Gonzalez, Deyarina

AU - Francis, Lewis

AU - Webb, Paul

AU - Conlan, R. Steven

PY - 2019/4/1

Y1 - 2019/4/1

N2 - New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone acetyltransferase HBO1 functions in regulating diverse molecular processes, including DNA repair, transcription and replication, and is highly expressed in primary ovarian cancer. Here we define both the molecular function and a role in cell biomechanics for HBO1 in ovarian cancer. HBO1 preferentially acetylates histone H4 through the concomitant overexpression of co-regulator JADE2, and is required for the expression of YAP1, an ovarian cancer oncogene and mechano-transductor signaling factor. HBO1 appears therefore to have a role in determining the mechano-phenotype in ovarian cancer cells, through both signal transduction processes, and the modulation of cell elasticity as observed using direct measurements on live cells via atomic force microscopy.

AB - New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone acetyltransferase HBO1 functions in regulating diverse molecular processes, including DNA repair, transcription and replication, and is highly expressed in primary ovarian cancer. Here we define both the molecular function and a role in cell biomechanics for HBO1 in ovarian cancer. HBO1 preferentially acetylates histone H4 through the concomitant overexpression of co-regulator JADE2, and is required for the expression of YAP1, an ovarian cancer oncogene and mechano-transductor signaling factor. HBO1 appears therefore to have a role in determining the mechano-phenotype in ovarian cancer cells, through both signal transduction processes, and the modulation of cell elasticity as observed using direct measurements on live cells via atomic force microscopy.

KW - Acetyltransferase

KW - Biomechanics

KW - Elasticity

KW - JADE

KW - YAP1

UR - http://www.scopus.com/inward/record.url?scp=85062703578&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062703578&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2019.01.017

DO - 10.1016/j.nano.2019.01.017

M3 - Article

VL - 17

SP - 254

EP - 265

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

T2 - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

ER -

ID: 47312062