HBO1 directs histone H4 specific acetylation, potentiating mechano-transduction pathways and membrane elasticity in ovarian cancer cells

Marcos Quintela, Douglas H. Sieglaff, Andrea Salvatore Gazze, Aijun Zhang, Deyarina Gonzalez, Lewis Francis, Paul Webb, R. Steven Conlan

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

New approaches to treat ovarian cancer, the fifth leading cause of cancer mortality among women, are being sought, with the targeting of epigenetic modulators now receiving much attention. The histone acetyltransferase HBO1 functions in regulating diverse molecular processes, including DNA repair, transcription and replication, and is highly expressed in primary ovarian cancer. Here we define both the molecular function and a role in cell biomechanics for HBO1 in ovarian cancer. HBO1 preferentially acetylates histone H4 through the concomitant overexpression of co-regulator JADE2, and is required for the expression of YAP1, an ovarian cancer oncogene and mechano-transductor signaling factor. HBO1 appears therefore to have a role in determining the mechano-phenotype in ovarian cancer cells, through both signal transduction processes, and the modulation of cell elasticity as observed using direct measurements on live cells via atomic force microscopy.

Original languageEnglish (US)
Pages (from-to)254-265
Number of pages12
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume17
DOIs
StatePublished - Apr 2019

Keywords

  • Acetyltransferase
  • Biomechanics
  • Elasticity
  • JADE
  • YAP1

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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