TY - JOUR
T1 - Hazard of Combining Allopurinol and Thiopurine
AU - Berns, Arnold
AU - Rubenfeld, Sheldon
AU - Rymzo, Walter T.
AU - Calabro, John J.
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1972/3/30
Y1 - 1972/3/30
N2 - To the Editor: Regarding the Clinicopathologic Conference of January 27, 1972,1 discussed by Dr. John J. Calabro involving a case of embryonal rhabdomyosarcoma in a 16-year-old boy, we wish to call attention to the effects of xanthine oxidase inhibitors on thiopurine metabolism. It is stated in the case record that the patient was discharged from the hospital “on a regimen of prednisone, 60 mg. allopurinol, 300 mg, 6-mercaptopurine (6-MP), 150 mg, and aspirin, 1.5 g, daily.” Two weeks later he presented with severe thrombocytopenia, a 10-point drop in hematocrit, leukopenia and severe epistaxis. In this respect, the case is similar.
AB - To the Editor: Regarding the Clinicopathologic Conference of January 27, 1972,1 discussed by Dr. John J. Calabro involving a case of embryonal rhabdomyosarcoma in a 16-year-old boy, we wish to call attention to the effects of xanthine oxidase inhibitors on thiopurine metabolism. It is stated in the case record that the patient was discharged from the hospital “on a regimen of prednisone, 60 mg. allopurinol, 300 mg, 6-mercaptopurine (6-MP), 150 mg, and aspirin, 1.5 g, daily.” Two weeks later he presented with severe thrombocytopenia, a 10-point drop in hematocrit, leukopenia and severe epistaxis. In this respect, the case is similar.
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U2 - 10.1056/NEJM197203302861321
DO - 10.1056/NEJM197203302861321
M3 - Letter
C2 - 5061067
AN - SCOPUS:0015529240
VL - 286
SP - 730
EP - 731
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 13
ER -