Abstract
Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a drug delivery vehicle releases a large payload upon tumor localization, is thus a promising alternative strategy against this lethal disease. Herein, we synthesize anti-carcinoembryonic antigen (CEA) half-antibody conjugated lipid-polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding nontargeted nanoparticles.
Original language | English (US) |
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Pages (from-to) | 914-920 |
Number of pages | 7 |
Journal | Molecular pharmaceutics |
Volume | 7 |
Issue number | 3 |
DOIs | |
State | Published - Jun 7 2010 |
Keywords
- Carcinoembryonic antigen
- Half-antibody
- Lipid-polymer nanoparticles
- Pancreatic cancer
- Targeted drug delivery
ASJC Scopus subject areas
- Pharmaceutical Science
- Molecular Medicine
- Drug Discovery