Haemopoietic stem cell transplantation for acute lymphoblastic leukaemia

Uday Popat, George Carrum, Helen Heslop

Research output: Contribution to journalReview article

16 Scopus citations

Abstract

The majority of children and some adults with acute lymphocytic leukaemia (ALL) can be cured with current intensive chemotherapy regimens. For those patients who relapse or who do not achieve remission, allogeneic haemopoietic stem cell transplantation (HSCT) offers the best chance for long-term disease control. Different sources of haemopoietic stem cells including marrow, peripheral blood, and cord blood are now available and the introduction of subablative regimens has increased the number of patients who are transplant candidates. Relapse remains the major cause of transplant failure and immunotherapy strategies post-transplant to augment the graft versus leukaemia effect are being explored.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalCancer Treatment Reviews
Volume29
Issue number1
DOIs
StatePublished - Jan 1 2003

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging

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