Haemophagocytic lymphohistiocytosis in inflammatory bowel disease with virus infection

Yuan Li, Xuefeng Xia, Jing Zhang, Zhiqiang Song, Liya Zhou, Yaopeng Zhang, Yonghui Huang, Yanyan Shi, Eamonn M M Quigley, Shigang Ding

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Patients with inflammatory bowel disease (IBD) are at risk of developing haemophagocytic lymphohistiocytosis (HLH) because of chronic systemic inflammation as well as exposure to immunosuppressive medications. The two main causes of HLH in IBD patients are infection with cytomegalovirus and Epstein-Barr virus. Patients with Crohn's disease are more susceptible to HLH than those with ulcerative colitis. The majority of cases are seen in people receiving an immunosuppressive regimen that included thiopurines.

Original languageEnglish (US)
Pages (from-to)78-82
Number of pages5
JournalPrzeglad Gastroenterologiczny
Issue number2
StatePublished - 2015


  • Cytomegalovirus
  • Epstein-Barr virus
  • Haemophagocytic lymphohistiocytosis
  • Inflammatory bowel disease
  • Thiopurines

ASJC Scopus subject areas

  • Gastroenterology


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