Haemolysis after T‐cell depleted bone marrow transplantation involving minor ABO incompatibility

Geoffrey R. Hazlehurst, Malcolm K. Brenner, Jennifer Z. Wimperis, Susan M. Knowles, H. Grant Prentice

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

9 recipients of T-cell depleted allogeneic bone marrows (8 group A, 1 group AB) from group 0 donors were monitored after transplantation. Free anti-A/B was demonstrable in 8 of the 9 recipients 10-19 d post-transplant, 5 patients developed a positive direct anti-globulin test and 7 showed a rise in bilirubin. The presence of antibody was generally unrelated to the infusion of incompatible plasma, although 2 patients who also received anti-CMV immunoglobulin subsequently shown to contain high titre IgG anti-A/B were more severely affected, sustaining a fall in Hb of up to 2 g/d. These observations suggest that, after T-cell depleted bone marrow transplantation, immunocompetent B lymphocytes of donor origin are transferred, secrete antibody in the recipient, and may be responsible for self-limiting haemolytic episodes.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalScandinavian Journal of Haematology
Volume37
Issue number1
DOIs
StatePublished - Jul 1986

Keywords

  • T‐cell depletion
  • haemolysis
  • minor incompatibility

ASJC Scopus subject areas

  • Hematology

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