TY - JOUR
T1 - Haemolysis after T‐cell depleted bone marrow transplantation involving minor ABO incompatibility
AU - Hazlehurst, Geoffrey R.
AU - Brenner, Malcolm K.
AU - Wimperis, Jennifer Z.
AU - Knowles, Susan M.
AU - Prentice, H. Grant
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1986/7
Y1 - 1986/7
N2 - 9 recipients of T-cell depleted allogeneic bone marrows (8 group A, 1 group AB) from group 0 donors were monitored after transplantation. Free anti-A/B was demonstrable in 8 of the 9 recipients 10-19 d post-transplant, 5 patients developed a positive direct anti-globulin test and 7 showed a rise in bilirubin. The presence of antibody was generally unrelated to the infusion of incompatible plasma, although 2 patients who also received anti-CMV immunoglobulin subsequently shown to contain high titre IgG anti-A/B were more severely affected, sustaining a fall in Hb of up to 2 g/d. These observations suggest that, after T-cell depleted bone marrow transplantation, immunocompetent B lymphocytes of donor origin are transferred, secrete antibody in the recipient, and may be responsible for self-limiting haemolytic episodes.
AB - 9 recipients of T-cell depleted allogeneic bone marrows (8 group A, 1 group AB) from group 0 donors were monitored after transplantation. Free anti-A/B was demonstrable in 8 of the 9 recipients 10-19 d post-transplant, 5 patients developed a positive direct anti-globulin test and 7 showed a rise in bilirubin. The presence of antibody was generally unrelated to the infusion of incompatible plasma, although 2 patients who also received anti-CMV immunoglobulin subsequently shown to contain high titre IgG anti-A/B were more severely affected, sustaining a fall in Hb of up to 2 g/d. These observations suggest that, after T-cell depleted bone marrow transplantation, immunocompetent B lymphocytes of donor origin are transferred, secrete antibody in the recipient, and may be responsible for self-limiting haemolytic episodes.
KW - T‐cell depletion
KW - haemolysis
KW - minor incompatibility
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U2 - 10.1111/j.1600-0609.1986.tb01763.x
DO - 10.1111/j.1600-0609.1986.tb01763.x
M3 - Article
C2 - 3532299
AN - SCOPUS:0022461521
VL - 37
SP - 1
EP - 3
JO - Scandinavian Journal of Haematology
JF - Scandinavian Journal of Haematology
SN - 0036-553X
IS - 1
ER -