HA/alginate hybrid composites prepared through bio-inspired nucleation

A. Tampieri, M. Sandri, E. Landi, G. Celotti, N. Roveri, M. Mattioli-Belmonte, L. Virgili, F. Gabbanelli, G. Biagini

Research output: Contribution to journalArticlepeer-review

87 Scopus citations


Poorly crystalline apatite has been directly nucleated on self-assembling alginate chains by neutralization synthesis to obtain a biomimetic artificial bone-like composite. It has been observed that in preparing HA/alginate composites, Ca2+ ions present on the apatitic surface cross-link the alginate chains to produce a material with different morphology and thermal stability, both functions of the HA/alginate weight ratio. In vitro tests were performed on different samples in terms of both the HA/alginate ratio and synthesis temperature. All the samples were cultured for seven days with MG63 osteoblast-like cells and then underwent morphological and biochemical analyses (MTT and ALP tests). Scaffolds showed a different solubility into the culture media, which was related to the temperature of synthesis and to the HA/alginate ratio. All our data confirm the ability of the tested materials to favour cell growth and to maintain their osteoblastic functionality, at least during the examined period.

Original languageEnglish (US)
Pages (from-to)343-351
Number of pages9
JournalActa Biomaterialia
Issue number3
StatePublished - May 2005


  • Alginate
  • Bone-like substitute
  • Nanocomposite
  • Self-assembling

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering
  • Biotechnology
  • Biochemistry
  • Molecular Biology


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