Hürthle cell carcinoma of the thyroid presenting as thyrotoxicosis

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4 Scopus citations


Objective: To report a case of hyperthyroidism associated with Hürthle cell carcinoma and to review the literature regarding this relationship. Methods: We describe the clinical, biochemical, radiologic, and pathologic data of a patient with Hürthle cellcarcinoma associated with thyrotoxicosis and reversible heart failure. We discuss the mechanistic aspects and review previously reported cases of functionalHürthle cellcarcinomas.Results: A 43-year-old womanpresented with thyrotoxicosis and nonischemic cardiomyopathy. She had a "hot" nodule inthe left lobe of the thyroid onsodium pertechnetate scan. She underwent a left hemithyroidectomy and isthmusectomy. Pathologic findings revealed a minimally invasive Hürthle cellcarcinoma. Onfollow-up, the dilated cardiomyopathy had resolved. The associationof thyroid carcinoma with thyrotoxicosis is rare.Conclusions: Some Hürthle cellcarcinomas canbe functionaland lead to thyrotoxicosis. To our knowledge, we present the first case of reversible dilated cardiomyopathy due to thyrotoxicosis originating from Hürthle cell carcinoma.

Original languageEnglish (US)
JournalEndocrine Practice
Issue number1
StatePublished - Jan 1 2012

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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