Abstract

Thanks to rapid progress in the development and application of molecular techniques to the assessment of the human gut microbiome, the true nature, diversity and metabolic potential of this 'hidden organ' are being revealed. Simultaneously, the complex physiological, immunological and metabolic interactions between host and microbiome are being untangled. By contrast, the probiotic concept has been with us for decades and, while supported more by fad and folklore in the past, is now gaining support, not only from experimental work in animal models, but also by well-designed studies in human diseases, most notably infectious diarrheas, inflammatory bowel disease and the irritable bowel syndrome.

Original languageEnglish (US)
Pages (from-to)593-603
Number of pages11
JournalCurrent Opinion in Pharmacology
Volume11
Issue number6
DOIs
StatePublished - Jan 1 2011

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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