Gut microbiota and gastrointestinal health: Current concepts and future directions

Q. Aziz, J. Doré, A. Emmanuel, F. Guarner, E. M M Quigley

Research output: Contribution to journalReview article

147 Scopus citations

Abstract

Background  The microbial community of the human gut - the enteric microbiota - plays a critical role functions that sustahealth and is a positive asset host defenses. recent years, our understanding of this so-called human 'super organism' has advanced, following characterization of fecal metagenomes which identified three core bacterial enterotypes, and based on basic and clinical research into the impact and consequences of microbiota biodiversity and change on gastrointestinal disorders and diseases. Purpose  This article considers current knowledge and future perspectives on the make-up and function of human gut microbiota, with a particular focus on altered microbiota and gastrointestinal disorders, nutritional influences on the gut microbiota, and the consequences for gastrointestinal health, as well as improved understanding of gut-microbiota-bracommunication.

Original languageEnglish (US)
Pages (from-to)4-15
Number of pages12
JournalNeurogastroenterology and Motility
Volume25
Issue number1
DOIs
StatePublished - Jan 1 2013

Keywords

  • Bragut axis
  • Functional
  • Gut
  • Microbiota

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Gastroenterology
  • Physiology

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