Abstract

A new era in medical science has dawned with the realization of the critical role of the "forgotten organ," the gut microbiota, in health and disease. Central to this beneficial interaction between the microbiota and host is the manner in which bacteria and most likely other microorganisms contained within the gut communicate with the host's immune system and participate in a variety of metabolic processes of mutual benefit to the host and the microbe. The advent of high-throughput methodologies and the elaboration of sophisticated analytic systems have facilitated the detailed description of the composition of the microbial constituents of the human gut, as never before, and are now enabling comparisons to be made between health and various disease states. Although the latter approach is still in its inflancy, some important insights have already been gained about how the microbiota might influence a number of disease processes both within and distant from the gut. These discoveries also lay the groundwork for the development of therapeutic strategies that might modify the microbiota (eg, through the use of probiotics). Although this area holds much promise, more high-quality trials of probiotics, prebiotics, and other microbiota-modifying approaches in digestive disorders are needed, as well as laboratory investigations of their mechanisms of action.

Original languageEnglish (US)
Pages (from-to)560-569
Number of pages10
JournalGastroenterology and Hepatology
Volume9
Issue number9
StatePublished - Sep 1 2013

Keywords

  • Gut bacteria
  • Gut flora
  • Microbial metabolism
  • Microbiota
  • Mucosal immunology
  • Probiotic

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

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