Guiding principles in the design of ligand-targeted nanomedicines

Bingbing Wang, Chris V. Galliford, Philip Low

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Medicines for the treatment of most human pathologies are encumbered by unwanted side effects that arise from the deposition of an effective drug into the wrong tissues. The logical remedy for these undesirable properties involves selective targeting of the therapeutic agent to pathologic cells, thereby avoiding collateral toxicity to healthy cells. Since significant advantages can also accrue by incorporating a therapeutic or imaging agent into a nanoparticle, many laboratories are now combining both benefits into a single formulation. This review will focus on the major guiding principles in the design of ligand-targeted nanoparticles, including optimization of their chemical and physical properties, selection of the ideal targeting ligand, engineering of the appropriate surface passivation and linker strategies to achieve selective delivery of the entrapped cargo to the desired diseased cell.

Original languageEnglish (US)
Pages (from-to)313-330
Number of pages18
JournalNanomedicine
Volume9
Issue number2
DOIs
StatePublished - Jan 1 2014

Keywords

  • Diagnostic imaging agent
  • Intracellular delivery
  • Ligand-targeted drug
  • Nanomedicine
  • Targeted nanoparticle

ASJC Scopus subject areas

  • Materials Science(all)
  • Bioengineering
  • Biomedical Engineering
  • Medicine (miscellaneous)
  • Development

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