Growth related oncogene-alpha (GRO-a): Roles in atherosclerosis, angiogenesis and other inflammatory conditions

Carlos F. Bechara, Hong Chai, Peter H. Lin, Qizhi Yao, Changyi Chen

Research output: Contribution to journalReview article

41 Scopus citations

Abstract

Growth related oncogene-alpha (GRO-α) is a member of the CXC chemokine family with an internal glutamate-leucine-arginine (ELR) motif. It was initially isolated and characterized by its growth stimulatory activity on malignant melanoma cells. Recently, many new functions and properties of GRO-α have been discovered and associated with atherosclerosis, angiogenesis and many inflammatory conditions. Purpose of this review is to overview current advances of multiple functions of GRO-α and its associated molecular mechanisms and clinical implications. We hope to further evaluate this molecule in the pathogenesis of atherosclerosis as well as angiogenesis to promote a background for therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)RA87-RA90
JournalMedical Science Monitor
Volume13
Issue number6
StatePublished - Jun 2007

Keywords

  • Angiogenesis
  • Atherosclerosis
  • Chemokine
  • Growth related oncogene-alpha
  • Inflammation

ASJC Scopus subject areas

  • Medicine(all)

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