Abstract
Growth related oncogene-alpha (GRO-α) is a member of the CXC chemokine family with an internal glutamate-leucine-arginine (ELR) motif. It was initially isolated and characterized by its growth stimulatory activity on malignant melanoma cells. Recently, many new functions and properties of GRO-α have been discovered and associated with atherosclerosis, angiogenesis and many inflammatory conditions. Purpose of this review is to overview current advances of multiple functions of GRO-α and its associated molecular mechanisms and clinical implications. We hope to further evaluate this molecule in the pathogenesis of atherosclerosis as well as angiogenesis to promote a background for therapeutic interventions.
| Original language | English (US) |
|---|---|
| Pages (from-to) | RA87-RA90 |
| Journal | Medical Science Monitor |
| Volume | 13 |
| Issue number | 6 |
| State | Published - Jun 2007 |
Keywords
- Angiogenesis
- Atherosclerosis
- Chemokine
- Growth related oncogene-alpha
- Inflammation
ASJC Scopus subject areas
- General Medicine