Graphdiyne Nanoparticles with High Free Radical Scavenging Activity for Radiation Protection

Jiani Xie, Ning Wang, Xinghua Dong, Chengyan Wang, Zhen Du, Linqiang Mei, Yuan Yong, Changshui Huang, Yuliang Li, Zhanjun Gu, Yuliang Zhao

Research output: Contribution to journalArticlepeer-review

115 Scopus citations


Numerous carbon networks materials comprised of benzene moieties, such as graphene and fullerene, have held great fascination for radioprotection because of their acknowledged good biocompatibility and strong free radical scavenging activity derived from their delocalized π-conjugated structure. Recently, graphdiyne, a new emerging carbon network material consisting of a unique chemical structure of benzene and acetylenic moieties, has gradually attracted attention in many research fields. Encouraged by its unique structure with strong conjugated π-system and highly reactive diacetylenic linkages, graphdiyne might have free radical activity and can thus be used as a radioprotector, which has not been investigated so far. Herein, for the first time, we synthesized bovine serum albumin (BSA)-modified graphdiyne nanoparticles (graphdiyne-BSA NPs) to evaluate their free radical scavenging ability and investigate their application for radioprotection both in cell and animal models. In vitro studies indicated that the graphdiyne-BSA NPs could effectively eliminate the free-radicals, decrease radiation-induced DNA damage in cells, and improve the viability of cells under ionizing radiation. In vivo experiments showed that the graphdiyne-BSA NPs could protect the bone marrow DNA of mice from radiation-induced damage and make the superoxide dismutase (SOD) and malondialdehyde (MDA) (two kinds of vital indicators of radiation-induced injury) recover back to normal levels. Furthermore, the good biocompatibility and negligible systemically toxicity responses of the graphdiyne-BSA NPs to mice were verified. All these results manifest the good biosafety and radioprotection activity of graphdiyne-BSA NPs to normal tissues. Therefore, our studies not only provide a new radiation protection platform based on graphdiyne for protecting normal tissues from radiation-caused injury but also provide a promising direction for the application of graphdiyne in the biomedicine field.

Original languageEnglish (US)
Pages (from-to)2579-2590
Number of pages12
JournalACS Applied Materials and Interfaces
Issue number3
StatePublished - Jan 23 2019


  • biosafety
  • free radical scavenger
  • graphdiyne
  • nanoparticles
  • radiation
  • radioprotection

ASJC Scopus subject areas

  • Materials Science(all)


Dive into the research topics of 'Graphdiyne Nanoparticles with High Free Radical Scavenging Activity for Radiation Protection'. Together they form a unique fingerprint.

Cite this