Gormonochuvstvitel'nost' perevivnoǐ adenokartsinomy tolstoǐ kishki.

L. M. Bershteǐn; M. A. Zabezhinskiǐ; A. N. Stukov; V. N. Kalikhevich; Andrei M Mikheev

Gormonochuvstvitel'nost' perevivnoǐ adenokartsinomy tolstoǐ kishki.

Translated title of the contribution: The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine

L. M. Bershteǐn, M. A. Zabezhinskiǐ, A. N. Stukov, V. N. Kalikhevich, Andrei M Mikheev

Houston Methodist

Research output: Contribution to journal › Article › peer-review

Abstract

It was found that repeated transplantation of ACATOL strain cells resulted in a loss of their sensitivity to growth-stimulating effect of pentagastrin. The effect of gastrin receptor antagonist proglumide, on ACATOL cells growth was inconstant. ACATOL tumor was sensitive to VIP and glucagon in vitro (as shown by adenylate cyclase activity assay), that makes the model promising for selecting potent hormone drugs against colorectal cancer.

Translated title of the contribution	The hormonal sensitivity of a transplantable adenocarcinoma of the large intestine
Original language	Russian
Pages (from-to)	62-64
Number of pages	3
Journal	Eksperimentalnaa onkologia
Volume	12
Issue number	5
State	Published - Jan 1 1990

ASJC Scopus subject areas

Oncology
Cancer Research

Cite this

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title = "Gormonochuvstvitel'nost' perevivnoǐ adenokartsinomy tolstoǐ kishki.",

abstract = "It was found that repeated transplantation of ACATOL strain cells resulted in a loss of their sensitivity to growth-stimulating effect of pentagastrin. The effect of gastrin receptor antagonist proglumide, on ACATOL cells growth was inconstant. ACATOL tumor was sensitive to VIP and glucagon in vitro (as shown by adenylate cyclase activity assay), that makes the model promising for selecting potent hormone drugs against colorectal cancer.",

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AU - Stukov, A. N.

AU - Kalikhevich, V. N.

AU - Mikheev, Andrei M

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N2 - It was found that repeated transplantation of ACATOL strain cells resulted in a loss of their sensitivity to growth-stimulating effect of pentagastrin. The effect of gastrin receptor antagonist proglumide, on ACATOL cells growth was inconstant. ACATOL tumor was sensitive to VIP and glucagon in vitro (as shown by adenylate cyclase activity assay), that makes the model promising for selecting potent hormone drugs against colorectal cancer.

AB - It was found that repeated transplantation of ACATOL strain cells resulted in a loss of their sensitivity to growth-stimulating effect of pentagastrin. The effect of gastrin receptor antagonist proglumide, on ACATOL cells growth was inconstant. ACATOL tumor was sensitive to VIP and glucagon in vitro (as shown by adenylate cyclase activity assay), that makes the model promising for selecting potent hormone drugs against colorectal cancer.

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ER -

Gormonochuvstvitel'nost' perevivnoǐ adenokartsinomy tolstoǐ kishki.

Abstract

ASJC Scopus subject areas

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