Gold nanoshell bioconjugates for molecular imaging in living cells

Christopher Loo, Leon Hirsch, Min Ho Lee, Emmanuel Chang, Jennifer West, Naomi Halas, Rebekah Drezek

Research output: Contribution to journalArticlepeer-review

311 Scopus citations

Abstract

Advances in scattering-based optical imaging technologies offer a new approach to noninvasive point-of-care detection, diagnosis, and monitoring of cancer. Emerging photonics technologies provide a cost-effective means to image tissue in vivo with high resolution in real time. Advancing the clinical potential of these imaging strategies requires the development of optical contrast agents targeted to specific molecular signatures of disease. We describe the use of a novel class of contrast agents based on nanoshell bioconjugates for molecular imaging in living cells. Nanoshells offer significant advantages over conventional imaging probes including continuous and broad wavelength tunability, far greater scattering and absorption coefficients, increased chemical stability, and improved biocompatibility. We show that nanoshell bioconjugates can be used to effectively target and image human epidermal growth factor receptor 2 (HER2), a clinically relevant biomarker, in live human breast carcinoma cells.

Original languageEnglish (US)
Pages (from-to)1012-1014
Number of pages3
JournalOptics Letters
Volume30
Issue number9
DOIs
StatePublished - May 1 2005

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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