Glucocorticoid regulation of hippocampal oxytocin receptor binding

Israel Liberzon; Derek T. Chalmers; Alfred Mansour; Juan F. Lopez; Stanley J. Watson; Elizabeth A. Young

doi:10.1016/0006-8993(94)91798-1

Glucocorticoid regulation of hippocampal oxytocin receptor binding

Israel Liberzon, Derek T. Chalmers, Alfred Mansour, Juan F. Lopez, Stanley J. Watson, Elizabeth A. Young

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33 Scopus citations

Abstract

The effects of glucocorticoid hormones on oxytocin receptors in rat hippocampus were investigated. Oxytocin receptor autoradiography (using 0.1 and 1.2 nM concentrations of [¹²⁵I]OVTA) revealed a significant (P < 0.02) decrease in oxytocin receptor binding in adrenalectomized animals 7 days after the surgery. Corticosterone replacement at the time of adrenalectomy prevented the decrease in oxytocin binding. The findings were significant in hippocampus and subiculum. These findings suggest regulation of oxytocin receptors, and possibly oxytocin-regulated behaviors by glucocorticoids.

Original language	English (US)
Pages (from-to)	317-322
Number of pages	6
Journal	Brain Research
Volume	650
Issue number	2
DOIs	https://doi.org/10.1016/0006-8993(94)91798-1
State	Published - Jul 11 1994

Keywords

Adrenalectomy
In vitro autoradiography
Subiculum
[I]OVTA

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(94)91798-1

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title = "Glucocorticoid regulation of hippocampal oxytocin receptor binding",

abstract = "The effects of glucocorticoid hormones on oxytocin receptors in rat hippocampus were investigated. Oxytocin receptor autoradiography (using 0.1 and 1.2 nM concentrations of [125I]OVTA) revealed a significant (P < 0.02) decrease in oxytocin receptor binding in adrenalectomized animals 7 days after the surgery. Corticosterone replacement at the time of adrenalectomy prevented the decrease in oxytocin binding. The findings were significant in hippocampus and subiculum. These findings suggest regulation of oxytocin receptors, and possibly oxytocin-regulated behaviors by glucocorticoids.",

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AU - Liberzon, Israel

AU - Chalmers, Derek T.

AU - Mansour, Alfred

AU - Lopez, Juan F.

AU - Watson, Stanley J.

AU - Young, Elizabeth A.

PY - 1994/7/11

Y1 - 1994/7/11

N2 - The effects of glucocorticoid hormones on oxytocin receptors in rat hippocampus were investigated. Oxytocin receptor autoradiography (using 0.1 and 1.2 nM concentrations of [125I]OVTA) revealed a significant (P < 0.02) decrease in oxytocin receptor binding in adrenalectomized animals 7 days after the surgery. Corticosterone replacement at the time of adrenalectomy prevented the decrease in oxytocin binding. The findings were significant in hippocampus and subiculum. These findings suggest regulation of oxytocin receptors, and possibly oxytocin-regulated behaviors by glucocorticoids.

AB - The effects of glucocorticoid hormones on oxytocin receptors in rat hippocampus were investigated. Oxytocin receptor autoradiography (using 0.1 and 1.2 nM concentrations of [125I]OVTA) revealed a significant (P < 0.02) decrease in oxytocin receptor binding in adrenalectomized animals 7 days after the surgery. Corticosterone replacement at the time of adrenalectomy prevented the decrease in oxytocin binding. The findings were significant in hippocampus and subiculum. These findings suggest regulation of oxytocin receptors, and possibly oxytocin-regulated behaviors by glucocorticoids.

KW - Adrenalectomy

KW - In vitro autoradiography

KW - Subiculum

KW - [I]OVTA

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Glucocorticoid regulation of hippocampal oxytocin receptor binding

Abstract

Keywords

ASJC Scopus subject areas

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