Glucocorticoid regulation of hippocampal oxytocin receptor binding

Israel Liberzon, Derek T. Chalmers, Alfred Mansour, Juan F. Lopez, Stanley J. Watson, Elizabeth A. Young

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

The effects of glucocorticoid hormones on oxytocin receptors in rat hippocampus were investigated. Oxytocin receptor autoradiography (using 0.1 and 1.2 nM concentrations of [125I]OVTA) revealed a significant (P < 0.02) decrease in oxytocin receptor binding in adrenalectomized animals 7 days after the surgery. Corticosterone replacement at the time of adrenalectomy prevented the decrease in oxytocin binding. The findings were significant in hippocampus and subiculum. These findings suggest regulation of oxytocin receptors, and possibly oxytocin-regulated behaviors by glucocorticoids.

Original languageEnglish (US)
Pages (from-to)317-322
Number of pages6
JournalBrain Research
Volume650
Issue number2
DOIs
StatePublished - Jul 11 1994

Keywords

  • Adrenalectomy
  • In vitro autoradiography
  • Subiculum
  • [I]OVTA

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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