TY - JOUR
T1 - Globus pallidus deep brain stimulation for refractory idiopathic restless legs syndrome
AU - Ondo, William G.
AU - Jankovic, Joseph
AU - Simpson, Richard
AU - Jimenez-Shahed, Joohi
PY - 2012/10
Y1 - 2012/10
N2 - Objective: The neuroanatomic substrate of restless legs syndrome (RLS) is unknown. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) and other targets is used to treat Parkinson's disease (PD), and RLS symptoms associated with PD have been reported to improve when GPi DBS is used in that population. We wish to test whether GPi DBS can improve idiopathic RLS. Method: We implanted bilateral GPi DBS in a subject with refractory idiopathic RLS. Results: The GPi cells recordings were dissimilar to those of PD. Clinically, the patient had a good, but far from complete, response, which more prominently affected the urge to move and involuntary movements than the painful component. Conclusion: DBS for RLS remains investigational.
AB - Objective: The neuroanatomic substrate of restless legs syndrome (RLS) is unknown. Deep brain stimulation (DBS) of the globus pallidus internus (GPi) and other targets is used to treat Parkinson's disease (PD), and RLS symptoms associated with PD have been reported to improve when GPi DBS is used in that population. We wish to test whether GPi DBS can improve idiopathic RLS. Method: We implanted bilateral GPi DBS in a subject with refractory idiopathic RLS. Results: The GPi cells recordings were dissimilar to those of PD. Clinically, the patient had a good, but far from complete, response, which more prominently affected the urge to move and involuntary movements than the painful component. Conclusion: DBS for RLS remains investigational.
KW - DBS
KW - Deep brain stimulation
KW - Globus pallidus internus
KW - Neurophysiology
KW - Restless legs syndrome
KW - Surgery
UR - http://www.scopus.com/inward/record.url?scp=84867470198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84867470198&partnerID=8YFLogxK
U2 - 10.1016/j.sleep.2012.06.007
DO - 10.1016/j.sleep.2012.06.007
M3 - Article
C2 - 22995627
AN - SCOPUS:84867470198
VL - 13
SP - 1202
EP - 1204
JO - Sleep Medicine
JF - Sleep Medicine
SN - 1389-9457
IS - 9
ER -