TY - JOUR
T1 - Global, Regional, and National Burden of Calcific Aortic Valve and Degenerative Mitral Valve Diseases, 1990-2017
AU - Yadgir, Simon
AU - Johnson, Catherine Owens
AU - Aboyans, Victor
AU - Adebayo, Oladimeji M.
AU - Adedoyin, Rufus Adesoji
AU - Afarideh, Mohsen
AU - Alahdab, Fares
AU - Alashi, Alaa
AU - Alipour, Vahid
AU - Arabloo, Jalal
AU - Azari, Samad
AU - Barthelemy, Celine M.
AU - Benziger, Catherine P.
AU - Berman, Adam E.
AU - Bijani, Ali
AU - Carrero, Juan J.
AU - Carvalho, Félix
AU - Daryani, Ahmad
AU - Durães, Andre R.
AU - Esteghamati, Alireza
AU - Farid, Talha A.
AU - Farzadfar, Farshad
AU - Fernandes, Eduarda
AU - Filip, Irina
AU - Gad, Mohamed M.
AU - Hamidi, Samer
AU - Hay, Simon I.
AU - Ilesanmi, Olayinka Stephen
AU - Naghibi Irvani, Seyed Sina
AU - Jürisson, Mikk
AU - Kasaeian, Amir
AU - Kengne, Andre Pascal
AU - Khan, Abdur Rahman
AU - Kisa, Adnan
AU - Kisa, Sezer
AU - Kolte, Dhaval
AU - Manafi, Navid
AU - Manafi, Amir
AU - Mensah, George A.
AU - Mirrakhimov, Erkin M.
AU - Mohammad, Yousef
AU - Mokdad, Ali H.
AU - Negoi, Ruxandra Irina
AU - Thi Nguyen, Huong Lan
AU - Nguyen, Trang Huyen
AU - Nixon, Molly R.
AU - Otto, Catherine M.
AU - Patel, Shanti
AU - Pilgrim, Thomas
AU - Radfar, Amir
AU - Rawaf, David Laith
AU - Rawaf, Salman
AU - Rawasia, Wasiq Faraz
AU - Rezapour, Aziz
AU - Roever, Leonardo
AU - Saad, Anas M.
AU - Saadatagah, Seyedmohammad
AU - Senthilkumaran, Subramanian
AU - Sliwa, Karen
AU - Tesfay, Berhe Etsay
AU - Tran, Bach Xuan
AU - Ullah, Irfan
AU - Vaduganathan, Muthiah
AU - Vasankari, Tommi Juhani
AU - Wolfe, Charles D.A.
AU - Yonemoto, Naohiro
AU - Roth, Gregory A.
N1 - Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/5/26
Y1 - 2020/5/26
N2 - Background: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017. Methods: Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017. Results: Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700-107 900) and 35 700 (95% UI, 30 500-42 500) deaths, and 12.6 million (95% UI, 11.4 million-13.8 million) and 18.1 million (95% UI, 17.6 million-18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million-2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%-0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%-117%) and 35% (95% UI, 23%-47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries. Conclusions: These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases.
AB - Background: Nonrheumatic valvular diseases are common; however, no studies have estimated their global or national burden. As part of the Global Burden of Disease Study 2017, mortality, prevalence, and disability-adjusted life-years (DALYs) for calcific aortic valve disease (CAVD), degenerative mitral valve disease, and other nonrheumatic valvular diseases were estimated for 195 countries and territories from 1990 to 2017. Methods: Vital registration data, epidemiologic survey data, and administrative hospital data were used to estimate disease burden using the Global Burden of Disease Study modeling framework, which ensures comparability across locations. Geospatial statistical methods were used to estimate disease for all countries, because data on nonrheumatic valvular diseases are extremely limited for some regions of the world, such as Sub-Saharan Africa and South Asia. Results accounted for estimated level of disease severity as well as the estimated availability of valve repair or replacement procedures. DALYs and other measures of health-related burden were generated for both sexes and each 5-year age group, location, and year from 1990 to 2017. Results: Globally, CAVD and degenerative mitral valve disease caused 102 700 (95% uncertainty interval [UI], 82 700-107 900) and 35 700 (95% UI, 30 500-42 500) deaths, and 12.6 million (95% UI, 11.4 million-13.8 million) and 18.1 million (95% UI, 17.6 million-18.6 million) prevalent cases existed in 2017, respectively. A total of 2.5 million (95% UI, 2.3 million-2.8 million) DALYs were estimated as caused by nonrheumatic valvular diseases globally, representing 0.10% (95% UI, 0.09%-0.11%) of total lost health from all diseases in 2017. The number of DALYs increased for CAVD and degenerative mitral valve disease between 1990 and 2017 by 101% (95% UI, 79%-117%) and 35% (95% UI, 23%-47%), respectively. There is significant geographic variation in the prevalence, mortality rate, and overall burden of these diseases, with highest age-standardized DALY rates of CAVD estimated for high-income countries. Conclusions: These global and national estimates demonstrate that CAVD and degenerative mitral valve disease are important causes of disease burden among older adults. Efforts to clarify modifiable risk factors and improve access to valve interventions are necessary if progress is to be made toward reducing, and eventually eliminating, the burden of these highly treatable diseases.
KW - aortic valve
KW - global burden of disease
KW - heart valve diseases
KW - mitral valve
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UR - http://www.scopus.com/inward/citedby.url?scp=85085466384&partnerID=8YFLogxK
U2 - 10.1161/CIRCULATIONAHA.119.043391
DO - 10.1161/CIRCULATIONAHA.119.043391
M3 - Article
C2 - 32223336
AN - SCOPUS:85085466384
SN - 0009-7322
VL - 141
SP - 1670
EP - 1680
JO - Circulation
JF - Circulation
IS - 21
ER -