TY - JOUR
T1 - Global genetic structure and molecular epidemiology of encapsulated haemophilus influenzae
AU - Musser, James M.
AU - Kroll, J. Simon
AU - Granoff, Dan M.
AU - Moxon, E. Richard
AU - Brodeur, Bernard R.
AU - Campos, Jose
AU - Dabernat, Henri
AU - Frederiksen, Wilhelm
AU - Hamel, Josee
AU - Hammond, Gregory
AU - Høiby, E. Arne
AU - Jonsdottir, Kristin E.
AU - Kabeer, Mustafa
AU - Kallings, Ingegerd
AU - Khan, Waheed N.
AU - Kilian, Mogens
AU - Knowles, Kathleen
AU - Koornhof, H. J.
AU - Law, Barbara
AU - Li, Karl I.
AU - Montgomery, Janet
AU - Pattison, Patricia E.
AU - Piffaretti, Jean Claude
AU - Takala, Aino K.
AU - Thong, Mee Len
AU - Wall, Robert A.
AU - Ward, Joel I.
AU - Selander, Robert K.
N1 - Funding Information:
Research leading to this review was supported by grant no. AI24332 from the National Institute of Allergy and Infectious Diseases (to R. K. S. and D. M, G.), by contract AID-2429-8-312 from the Board on Scienceand Technologyfor International Development (BOSTID), National Research Council (to D. M. G.), by a Program Grant from the Medical Research Council, U.K. (to E. R. M.), and by grant 8S.3.16.8.Efrom the Caisse Nationale d'Assurances Maladie des Travailleurs Salaries (to H. D.). J. S. K. is a Lister Institute Research Fellow.
PY - 1990/1
Y1 - 1990/1
N2 - A collection of 2,209 isolates of six polysaccharide capsule types of Haemophilus influenzae, including 1,975 serotype b isolates recovered in 30 countries was characterized for electrophoretically demonstrable allele profiles at 17 metabolic enzyme loci. Two hundred eighty distinct multilocus genotypes were distinguished, and cluster analysis revealed two primary phylogenetic divisions. The population structure of encapsulated H. influenzae is clonal. Currently, most of the invasive disease worldwide is caused by serotype b strains of nine clones. Strains producing serotype c, e, and f capsules belong to single divisions and have no close genetic relationships to strains of other serotypes. Serotype a and b strains occur in both primary phylogenetic divisions, probably as a result of transfer and recombination of serotype-specific sequences of the cap region between clonal lineages. A close genetic relatedness between serotype d isolates and some strains of serotypes a and b was identified. There are strong patterns of geographic variation, on an intercontinental scale, in both the extent of genetic diversity and the clonal composition of populations of encapsulated strains. The analysis suggest that the present distribution of clones is, in part, related to patterns of racial or ethnic differentiation and historical demographic movements of the human host populations.
AB - A collection of 2,209 isolates of six polysaccharide capsule types of Haemophilus influenzae, including 1,975 serotype b isolates recovered in 30 countries was characterized for electrophoretically demonstrable allele profiles at 17 metabolic enzyme loci. Two hundred eighty distinct multilocus genotypes were distinguished, and cluster analysis revealed two primary phylogenetic divisions. The population structure of encapsulated H. influenzae is clonal. Currently, most of the invasive disease worldwide is caused by serotype b strains of nine clones. Strains producing serotype c, e, and f capsules belong to single divisions and have no close genetic relationships to strains of other serotypes. Serotype a and b strains occur in both primary phylogenetic divisions, probably as a result of transfer and recombination of serotype-specific sequences of the cap region between clonal lineages. A close genetic relatedness between serotype d isolates and some strains of serotypes a and b was identified. There are strong patterns of geographic variation, on an intercontinental scale, in both the extent of genetic diversity and the clonal composition of populations of encapsulated strains. The analysis suggest that the present distribution of clones is, in part, related to patterns of racial or ethnic differentiation and historical demographic movements of the human host populations.
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U2 - 10.1093/clinids/12.1.75
DO - 10.1093/clinids/12.1.75
M3 - Article
C2 - 1967849
AN - SCOPUS:0025177273
SN - 0162-0886
VL - 12
SP - 75
EP - 111
JO - Reviews of Infectious Diseases
JF - Reviews of Infectious Diseases
IS - 1
ER -