Glial-neural interaction demonstrated by the injection of Na+ and Li+ into cortical glia

Robert G. Grossman, Aleksandr Seregin

Research output: Contribution to journalArticle

12 Scopus citations


Injection of Na+ or Li+ into cortical glia evokes glial depolarization, discharge of adjacent neurons, and vascular pulsation. The effects can be explained by the extrusion of K+ from glia after cation injection, glial swelling, and the slow removal of the cation from glia. The data suggest that the reduced rate of reuptake of K+ into Na+ loaded glia results in epileptiform firing of neurons, and support the hypothesis that glia function to buffer the environment of neurons.

Original languageEnglish (US)
Pages (from-to)196-198
Number of pages3
Issue number4274
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • General

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