TY - JOUR
T1 - Glial-neural interaction demonstrated by the injection of Na+ and Li+ into cortical glia
AU - Grossman, Robert G.
AU - Seregin, Aleksandr
PY - 1977/1/1
Y1 - 1977/1/1
N2 - Injection of Na+ or Li+ into cortical glia evokes glial depolarization, discharge of adjacent neurons, and vascular pulsation. The effects can be explained by the extrusion of K+ from glia after cation injection, glial swelling, and the slow removal of the cation from glia. The data suggest that the reduced rate of reuptake of K+ into Na+ loaded glia results in epileptiform firing of neurons, and support the hypothesis that glia function to buffer the environment of neurons.
AB - Injection of Na+ or Li+ into cortical glia evokes glial depolarization, discharge of adjacent neurons, and vascular pulsation. The effects can be explained by the extrusion of K+ from glia after cation injection, glial swelling, and the slow removal of the cation from glia. The data suggest that the reduced rate of reuptake of K+ into Na+ loaded glia results in epileptiform firing of neurons, and support the hypothesis that glia function to buffer the environment of neurons.
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U2 - 10.1126/science.831270
DO - 10.1126/science.831270
M3 - Article
C2 - 831270
AN - SCOPUS:0017347606
VL - 195
SP - 196
EP - 198
JO - Science (New York, N.Y.)
JF - Science (New York, N.Y.)
SN - 0036-8075
IS - 4274
ER -