Glial lipid droplets and ROS induced by mitochondrial defects promote neurodegeneration

Lucy Liu, Ke Zhang, Hector Sandoval, Shinya Yamamoto, Manish Jaiswal, Elisenda Sanz, Zhihong Li, Jessica Hui, Brett H Graham, Albert Quintana, Hugo J Bellen

Research output: Contribution to journalArticle

294 Scopus citations

Abstract

Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in neurodegenerative disease. Here, we find that a key consequence of ROS and neuronal mitochondrial dysfunction is the accumulation of lipid droplets (LD) in glia. In Drosophila, ROS triggers c-Jun-N-terminal Kinase (JNK) and Sterol Regulatory Element Binding Protein (SREBP) activity in neurons leading to LD accumulation in glia prior to or at the onset of neurodegeneration. The accumulated lipids are peroxidated in the presence of ROS. Reducing LD accumulation in glia and lipid peroxidation via targeted lipase overexpression and/or lowering ROS significantly delays the onset of neurodegeneration. Furthermore, a similar pathway leads to glial LD accumulation in Ndufs4 mutant mice with neuronal mitochondrial defects, suggesting that LD accumulation following mitochondrial dysfunction is an evolutionarily conserved phenomenon, and represents an early, transient indicator and promoter of neurodegenerative disease.

Original languageEnglish (US)
Pages (from-to)177-90
Number of pages14
JournalCell
Volume160
Issue number1-2
DOIs
StatePublished - Jan 15 2015

Keywords

  • Animals
  • Electron Transport Complex I
  • Lipid Droplets
  • MAP Kinase Kinase 4
  • Mice
  • Mice, Knockout
  • Mitochondria
  • Neurodegenerative Diseases
  • Neuroglia
  • Neurons
  • Reactive Oxygen Species
  • Sterol Regulatory Element Binding Proteins
  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

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